Irisin promotes proliferation but inhibits differentiation in osteoclast precursor cells

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Yaxian MaLiangzhi Xu

Abstract

The receptor activator of NF-κB ligand-induced osteoclast differentiation has a critical role in the process of bone metabolism. Overactivation of osteoclastogenesis may result in a series of diseases. Irisin, a novel myokine, which was first reported in 2012, has been proposed to mediate the beneficial metabolic effects of exercise. Studies have demonstrated that irisin targets osteoblasts by promoting osteoblast proliferation and differentiation; however, the underlying mechanism regarding the effect of irisin on osteoclasts remains elusive. Using 2 types of osteoclast precursor cells, RAW264.7 cells and mouse bone marrow monocytes, we showed that irisin promoted osteoclast precursor cell proliferation but inhibited osteoclast differentiation. Irisin down-regulated the expression of osteoclast differentiation marker genes, including receptor activators of NF-κB, nuclear factor of activated T cells, cytoplasmic 1, cathepsin K, and tartrate-resistant acid phosphatase (TRAP), as well as decreasing the number of TRAP-positive multinucleated cells and hydroxyapatite resorption pits. Furthermore, we showed that irisin suppressed the NF-κB signaling pathway, but activated the p38 and JNK signaling pathways. In the presence of an inh...Continue Reading

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Citations

Feb 6, 2020·Journal of Cellular Physiology·Sascha DrewloHamid-Reza Kohan-Ghadr
Feb 19, 2020·Oral Diseases·Jiaqi ZhuHong He
Apr 23, 2020·Climacteric : the Journal of the International Menopause Society·Y LuoL Xu
Jun 24, 2020·Journal of Cellular Physiology·Xiaofang ZhuJake J Chen
Apr 8, 2020·Cell & Bioscience·Farzaneh RabieeKamran Ghaedi
Jan 16, 2021·Biochemical Society Transactions·Cinzia BuccolieroMaria Grano
Dec 18, 2019·International Journal of Biological Macromolecules·Wenbin YeZhenqi Ding
Dec 29, 2020·Frontiers in Cell and Developmental Biology·Chen HeChangjun Li
Aug 14, 2019·Menopause : the Journal of the North American Menopause Society·Kunyan ZhouDan Shan
Mar 3, 2021·International Journal of Biological Macromolecules·Xintong ZhongQiang Yang
Oct 17, 2020·Scientific Reports·Yunyao LuoLiangzhi Xu
Nov 7, 2019·Menopause : the Journal of the North American Menopause Society·Kunyan ZhouDan Shan
Feb 11, 2021·Journal of Bone and Mineral Metabolism·Naoyuki KawaoHiroshi Kaji
Jan 9, 2022·Journal of Cachexia, Sarcopenia and Muscle·Naoyuki KawaoHiroshi Kaji

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