Irisin response to downhill running exercise in humans

Journal of Exercise Nutrition & Biochemistry
Yoshifumi TsuchiyaKazushige Goto

Abstract

To determine the effects of exercise-induced muscle damage, we examined irisin responses during level running (LR), with less muscle damage, and downhill running (DHR), with greater muscle damage under equivalent exercise duration and oxygen consumption (⩒O2) conditions. Fifteen healthy men (age: 21.6 ± 2.0 y, height: 170 ± 1.3 cm, weight: 64.8 ± 2.7 kg) were randomly assigned to either the LR group (n = 8) or the DHR group (n = 7). Subjects in the LR group performed treadmill running at 70% of maximum oxygen uptake (⩒O2max) for 30 min on a 0% gradient. In contrast, subjects in the DHR group performed the same exercise on a -10% gradient. Blood samples were collected before exercise, immediately after exercise, and 1, 3, and 24 h after exercise. No significant interaction (group × time) or main effect of group or time was observed for changes in plasma irisin concentrations over time (P > 0.05). However, the area under the curve of plasma irisin concentrations during a 3-h post-exercise period was significantly greater in the DHR (239,197 ± 8,166 ng/mL) group than in the LR (92,293 ± 8,755 ng/ml) group (P < 0.05). The blood lactate, serum cortisol, myoglobin, and plasma interleukin-6 concentrations were significantly higher in ...Continue Reading

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Citations

Jun 24, 2020·Journal of Cellular Physiology·Xiaofang ZhuJake J Chen
Oct 11, 2020·Sports Medicine·Bastien BontempsJulien Louis

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
blood collection

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