IRL-1620, an endothelin-B receptor agonist, enhanced radiation induced reduction in tumor volume in Dalton's Lymphoma Ascites tumor model.

Arzneimittel-Forschung
A GulatiG Kuttan

Abstract

ETB receptor agonist, IRL-1620 (or SPI-1620) presently in US Phase 1 clinical trial, has been demonstrated to selectively and transiently increase tumor blood flow. The present study was conducted to determine the effect of IRL-1620 on radiation therapy in tumor bearing mice inoculated with Dalton's Lymphoma Ascites cells. Tumors were allowed to grow for 30 days to a size of 1.10-1.29 cm3 before starting the treatment. The animals with or without IRL-1620 treatment were exposed to radiation (4 Gy/dose) on every alternate day for a total of 5 doses. Tumor volume was determined twice every week till the end of study. Radiation alone did not affect the tumor volume; however, animals treated with IRL-1620 followed by radiation produced a significant (64%) reduction in tumor volume. Survival of mice improved from 0/10 at 56 days after tumor inoculation in vehicle plus radiation group to 6/10 at 70 days in IRL-1620 (9 nmol/kg) plus radiation group. It is concluded that IRL-1620 improves the efficacy of radiation treatment in tumor bearing mice. (These findings have been earlier presented as an abstract ).

Citations

Jul 26, 2013·Nature Reviews. Cancer·Laura RosanòAnna Bagnato
Mar 10, 2016·Pharmacological Reviews·Anthony P DavenportJanet J Maguire
Aug 19, 2014·British Journal of Pharmacology·J J Maguire, A P Davenport
Nov 5, 2019·Hypertension·Matthias Barton, Masashi Yanagisawa
Mar 22, 2020·Journal of Clinical Medicine·Frederik C EnevoldsenMarcus Krüger

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