Aug 17, 2018

iRNA-2OM: A Sequence-Based Predictor for Identifying 2'-O-Methylation Sites in Homo sapiens

Journal of Computational Biology : a Journal of Computational Molecular Cell Biology
Hui YangHao Lin

Abstract

2'-O-methylation plays an important biological role in gene expression. Owing to the explosive increase in genomic sequencing data, it is necessary to develop a method for quickly and efficiently identifying whether a sequence contains the 2'-O-methylation site. As an additional method to the experimental technique, a computational method may help to identify 2'-O-methylation sites. In this study, based on the experimental 2'-O-methylation data of Homo sapiens, we proposed a support vector machine-based model to predict 2'-O-methylation sites in H. sapiens. In this model, the RNA sequences were encoded with the optimal features obtained from feature selection. In the fivefold cross-validation test, the accuracy reached 97.95%.

Mentioned in this Paper

Support Vector Machines
Study
Dimethoxymethane
Protein Methylation
Genome
Cosuppression
Binding Sites, Antibody
Cross Validation
Gene Expression
Computer Programs and Programming

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