Jan 26, 2016

IRNdb: The database of immunologically relevant non-coding RNAs.

BioRxiv : the Preprint Server for Biology
Elena DenisenkoSebastian Schmeier

Abstract

MicroRNAs (miRNAs), long non-coding RNAs (lncRNAs) and other functional non-coding RNAs (ncRNAs) have emerged as pivotal regulators involved in multiple biological processes. Recently, ncRNA control of gene expression has been identified as a critical regulatory mechanism in the immune system. Despite the great efforts made to discover and characterize ncRNAs, the functional role for most remains unknown. To facilitate discoveries in ncRNA regulation of immune system related processes we developed the database of immunologically relevant ncRNAs (IRNdb), a database of ncRNAs, their immunologically relevant targets, associated biological pathways and experiments. We integrated mouse data on predicted and experimentally verified ncRNA-target interactions, ncRNA and gene annotations, biological pathways and processes, and experimental data in a uniform format with a user-friendly web interface. The current version of IRNdb documents 3,799 experimentally confirmed miRNA-target interactions between 265 miRNAs and 1,633 murine and human-derived immune-related targets. In addition, we recorded 22,453 lncRNA - immune target and 377 PIWI-interacting RNA - immune target interactions. IRNdb is a comprehensive searchable data repository whi...Continue Reading

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Mentioned in this Paper

Biochemical Pathway
Immune System
NcRNA Processing
RNA, Untranslated
Murine
Gene Expression
Piwi-Interacting RNA
Long Intergenic Non-Protein Coding RNA
RNA, Long Untranslated
Gene Annotation

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