PMID: 6963546Jan 1, 1982Paper

Iron absorption by the premature infant. The effect of transfusion and iron supplements on the serum ferritin levels

Acta Paediatrica Scandinavica. Supplement
J C Shaw

Abstract

The amount of iron in a 1.0 kg preterm infant at birth is sufficient to synthesise only about 18.0 grams of haemoglobin. Since breast milk contains only 40 microgramsFe/100 ml, anaemia will develop in a premature baby fed breast milk unless supplementary iron is given. Preterm infants fed on breast milk are in negative iron balance averaging -0.24 mg/kg X day for at least thirty days after birth, and it can be estimated that they require an intake of about 0.6 mg/kg X day to compensate for obligatory intestinal iron losses. Insensible skin losses, estimated from measurements in adults, are small--of the order of 0.02 micrograms/kg X day, but losses due to venesection may be considerable since each gram of haemoglobin contains 3.4 mg of iron. Absorption of supplementary iron by preterm infants is a linear function of intake, which suggests immature control of iron absorption. Giving blood transfusions seem to diminish iron absorption but may not prevent it altogether. Giving repeated blood transfusions results in high serum ferritin levels similar to those seen in iron overload--however these levels decline spontaneously with age. Preterm infants who are given repeated transfusions do not require iron supplements until the trans...Continue Reading

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Citations

May 28, 2013·Seminars in Fetal & Neonatal Medicine·Deborah L O'Connor, Sharon Unger
Mar 14, 2001·Early Human Development·C DaniF F Rubaltelli
Apr 26, 2001·Archives of Disease in Childhood. Fetal and Neonatal Edition·K HiranoT Ogihara
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Jan 24, 2009·Clinics in Perinatology·Raghavendra Rao, Michael K Georgieff
Dec 13, 2006·Seminars in Fetal & Neonatal Medicine·Raghavendra Rao, Michael K Georgieff
May 4, 2002·Seminars in Neonatology : SN·R Rao, M K Georgieff
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Dec 14, 2017·Pediatrics International : Official Journal of the Japan Pediatric Society·Fotini StripeliLydia Kossiva
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Oct 10, 2009·Journal of Pediatric Hematology/oncology·Ece YapakçiNamik Ozbek
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Aug 21, 2021·Journal of Pediatric Gastroenterology and Nutrition·Richard J Cooke, Ian Griffin
Sep 23, 2021·The Proceedings of the Nutrition Society·Elaine K McCarthyMairead E Kiely

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