Iron: an emerging factor in colorectal carcinogenesis.

World Journal of Gastroenterology : WJG
Anita C G ChuaDebbie Trinder

Abstract

The carcinogenic potential of iron in colorectal cancer (CRC) is not fully understood. Iron is able to undergo reduction and oxidation, making it important in many physiological processes. This inherent redox property of iron, however, also renders it toxic when it is present in excess. Iron-mediated generation of reactive oxygen species via the Fenton reaction, if uncontrolled, may lead to cell damage as a result of lipid peroxidation and oxidative DNA and protein damage. This may promote carcinogenesis through increased genomic instability, chromosomal rearrangements as well as mutations of proto-oncogenes and tumour suppressor genes. Carcinogenesis is also affected by inflammation which is exacerbated by iron. Population studies indicate an association between high dietary iron intake and CRC risk. In this editorial, we examine the link between iron-induced oxidative stress and inflammation on the pathogenesis of CRC.

References

Jan 1, 1992·Free Radical Biology & Medicine·C F Babbs
Jan 1, 1990·Free Radical Biology & Medicine·C F Babbs
Nov 1, 1990·The New England Journal of Medicine·A EkbomH O Adami
Sep 1, 1990·International Journal of Epidemiology·K MerkM Björkholm
Sep 1, 1988·The New England Journal of Medicine·B VogelsteinJ L Bos
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R StockerB N Ames
Nov 14, 1985·The New England Journal of Medicine·C NiederauG Strohmeyer
Dec 1, 1974·The Journal of Clinical Investigation·S B RaffinR Schmid
Jun 1, 1982·Gut·P PriorR N Allan
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·D C JenkinsS Moncada
Jan 16, 1995·FEBS Letters·S ToyokuniH Hiai
Jan 17, 1995·International Journal of Cancer. Journal International Du Cancer·A W HsingJ F Fraumeni
Mar 16, 1994·Journal of the National Cancer Institute·R L NelsonP Bowen
Feb 1, 1994·International Journal of Cancer. Journal International Du Cancer·P KnektT Hakulinen
Jul 1, 1996·American Journal of Epidemiology·C L BirdR W Haile
Oct 18, 1996·Cell·K W Kinzler, B Vogelstein
Jun 1, 1997·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·G RimbachJ Pallauf
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·K D Poss, S Tonegawa
May 20, 1998·Archives of Biochemistry and Biophysics·M MinettiD Pietraforte
Sep 4, 1998·Science·T C HeK W Kinzler
Feb 27, 1999·International Journal of Cancer. Journal International Du Cancer·I KatoE Riboli
Jun 8, 1999·Journal of the National Cancer Institute·J D Potter
Jan 14, 2000·Journal of Gastroenterology and Hepatology·G A MacdonaldB A Leggett
Jan 22, 2000·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·H Deneo-PellegriniM Mendilaharsu
Apr 1, 2000·Current Opinion in Chemical Biology·P R Montellano
Mar 7, 2001·Lancet·F Balkwill, A Mantovani
Dec 12, 2001·Alimentary Pharmacology & Therapeutics·J CarrierJ P Allard
Feb 22, 2002·International Journal of Cancer. Journal International Du Cancer·Teresa NoratElio Riboli
Apr 4, 2002·Proceedings of the National Academy of Sciences of the United States of America·Gaël NicolasSophie Vaulont
Jul 20, 2002·Blood Reviews·Günter Weiss
Jul 20, 2002·Blood·Viktória JeneyGyörgy Balla
Aug 16, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Hongyun SheHidekazu Tsukamoto
Sep 21, 2002·Biochimica Et Biophysica Acta·Nghia T V Le, Des R Richardson
Oct 9, 2002·The Journal of Clinical Investigation·Gaël NicolasSophie Vaulont

❮ Previous
Next ❯

Citations

Aug 12, 2010·Techniques in Coloproctology·G ChristodoulidisK Tepetes
Apr 5, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Weidong ChenHongliang Yao
Aug 14, 2012·Cell Reports·Sorina RadulescuOwen J Sansom
Mar 20, 2012·Antioxidants & Redox Signaling·Angelica M MerlotDes R Richardson
Dec 22, 2012·The Journal of Clinical Investigation·Jennifer M NotoRichard M Peek
Dec 14, 2012·PloS One·Joanna L DaviesChris C Holmes
Jul 3, 2013·Nutrients·Xiang Xue, Yatrik M Shah
Jul 28, 2013·Nutrients·Jessica L HeathDaniel S Wechsler
May 30, 2014·Nutrition & Metabolism·Cenk K PusatciogluCarol Braunschweig
Apr 10, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Agustin CastiellaJosé Ignacio Emparanza
Feb 25, 2011·Chemico-biological Interactions·Ganesh Chandra Jagetia, Tiyagura Koti Reddy
Feb 13, 2013·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·S SharmaL N Kolonel
Jun 26, 2015·Cell Biology International·Attila MisetaKatalin Sipos
Sep 11, 2014·FEMS Microbiology Reviews·Guus A M KortmanHarold Tjalsma
Jul 5, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Takeshi NakanishiTakahiro Kuragano
Nov 28, 2013·Critical Reviews in Oncology/hematology·Yves BeguinAnders Osterborg
May 27, 2015·Nutrition Reviews·Hari PadmanabhanTariq Iqbal
Jul 8, 2017·Current Medicinal Chemistry·Angelica M MerlotDes R Richardson
Dec 31, 2011·Molecular and Cellular Biochemistry·Nathan VandjelovicYunbo Li
Feb 1, 2011·Genetic Testing and Molecular Biomarkers·Laura Alencastro de AzevedoSimone Martins de Castro
Jul 18, 2020·Nutrition Reviews·Oliver PhippsHafid O Al-Hassi
Feb 19, 2016·Annals of the New York Academy of Sciences·David H ManzSuzy V Torti
Dec 12, 2018·Frontiers in Oncology·Christa Pfeifhofer-ObermairManfred Nairz
Mar 27, 2020·NPJ Biofilms and Microbiomes·Shuping LongLiang Qiao
Apr 14, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Zarith Nameyrra Md NesranAmin Ismail
Apr 11, 2019·International Journal of Oncology·Ying ChenChunyan Gu
Jan 1, 2014·ISRN Hepatology·Hidenao NoritakeTakafumi Suda
Sep 25, 2017·Metallomics : Integrated Biometal Science·F SchlottmannG O Latunde-Dada
Sep 22, 2020·The Biochemical Journal·Sathish SivaprakasamVadivel Ganapathy
Mar 30, 2021·Frontiers in Immunology·Aysegül AksanJürgen Stein
Apr 18, 2021·Archives of Medical Research·Shogo ImanakaHiroshi Kobayashi
Jul 30, 2016·Bioconjugate Chemistry·Eman A Akam, Elisa Tomat

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.