Iron and copper accumulation in the brain of coxsackievirus-infected mice exposed to cadmium

Environmental Research
N-G IlbäckFrank Watt

Abstract

Cadmium (Cd) is a potentially toxic metal widely distributed in the environment and known to cause adverse health effects in humans. During coxsackievirus infection, the concentrations of essential and nonessential trace elements (e.g., iron (Fe), copper (Cu), and Cd) change in different target organs of the infection. Fe and Cu are recognized cofactors in host defence reactions, and Fe is known to be associated with certain pathological conditions of the brain. However, whether nonessential trace elements could influence the balance of essential trace elements in the brain is unknown. In this study the brain Fe, Cu, and Cd contents were measured through inductively coupled plasma mass spectrometry and their distributions determined by nuclear microscopy in the early phase (day 3) of coxsackievirus B3 (CB3) infection in nonexposed and in Cd-exposed female Balb/c mice. In CB3 infection the brain is a well-known target that has not been studied with regard to trace element balance. The brain concentration of Cu compared with that of noninfected control mice was increased by 9% (P < 0.05) in infected mice not exposed to Cd and by 10% (not significant) in infected Cd-exposed mice. A similar response was seen for Fe, which in infect...Continue Reading

References

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Apr 30, 2003·Biological Trace Element Research·Nils-Gunnar IlbäckGöran Friman
Oct 14, 2003·Toxicology and Applied Pharmacology·Wei ZhengJean-Francois Ghersi-Egea
Dec 6, 2005·Biological Trace Element Research·Nils-Gunnar IlbäckFrank Watt

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Citations

Sep 4, 2008·Journal of Pharmacological and Toxicological Methods·Nils-Gunnar IlbäckGöran Friman
Jun 21, 2008·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Nils-Gunnar IlbäckGöran Friman
Dec 23, 2014·Environmental Toxicology and Pharmacology·Samuel Jerry CobbinaLiuqing Yang

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