PMID: 16629175Apr 25, 2006Paper

Iron and glutathione at the crossroad of redox metabolism in neurons

Biological Research
Paula AracenaMarco T Núñez

Abstract

Neurons, as non-dividing cells, encounter a myriad of stressful conditions throughout their lifespan. In particular, there is increasing evidence that iron progressively accumulates in the brain with age and that iron induced oxidative stress is the cause of several forms of neurodegeneration. Here, we review recent evidence that gives support to the following notions: 1) neuronal iron accumulation leads to oxidative stress and cell death; 2) neuronal survival to iron accumulation associates with decreased expression of the iron import transporter DMT1 and increased expression of the efflux transporter IREG1; and 3) the adaptive process of neurons towards iron-induced oxidative stress includes a marked increase in both the expression of the catalytic subunit of gamma glutamate-cysteine ligase and glutathione. These findings may help to understand aging-related neurodegeneration hallmarks: oxidative damage, functional impairment and cell death.

Citations

Jun 19, 2008·Apoptosis : an International Journal on Programmed Cell Death·Vladimir LesnikovH Joachim Deeg
Oct 22, 2010·Cold Spring Harbor Perspectives in Biology·Johanna T LannerSusan L Hamilton
Feb 9, 2016·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Elizabeth BautistaJosé Segovia
Mar 8, 2016·Brain Research·Rahul Patel, Federico Sesti
Aug 12, 2008·Neurochemistry International·Melina V MateosNorma M Giusto
Sep 18, 2007·Progress in Neurobiology·Ya Ke, Zhong Ming Qian
Dec 6, 2006·Journal of Cellular Physiology·Nevenka JuretićNora Riveros
Mar 17, 2010·BioFactors·Gabriela A Salvador
Jun 12, 2013·Mitochondrion·Ruth Noriega-CisnerosAlfredo Saavedra-Molina
Mar 15, 2015·Metallomics : Integrated Biometal Science·Sudipta ChakrabortyMichael Aschner
Aug 15, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Wei ZhengZhan-You Wang
Apr 1, 2020·Frontiers in Aging Neuroscience·Rafael FrancoEva Martínez-Pinilla
Dec 10, 2020·International Journal of Molecular Sciences·Grażyna GromadzkaAgata Adamczyk

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