PMID: 6413777Jan 1, 1983Paper

Iron and haemochromatosis

Journal of Inherited Metabolic Disease
M Worwood

Abstract

There have recently been considerable advances in the understanding of the inheritance of idiopathic haemochromatosis (McKusick 23520). The disorder is determined by a locus closely linked to the HLA loci on the short arm of chromosome 6. There is a recessive mode of transmission. The gene frequency may be as high as 0.05 in some parts of the world. HLA typing makes it possible to identify family members who are homozygous for idiopathic haemochromatosis and measurement of transferrin saturation and serum ferritin concentration will identify those with iron overload. Treatment is by regular phlebotomy. Few advances have been made in the 50 years in the understanding of the abnormality which permits the increased absorption of iron and which causes the iron overload.

References

Jul 26, 1979·The New England Journal of Medicine·C BeaumontM Bourel
Jul 26, 1979·The New England Journal of Medicine·G E CartwrightL Buskjaer
May 12, 1978·JAMA : the Journal of the American Medical Association·K S OlssonF Staugárd
Jul 1, 1978·Archives of Internal Medicine·J W HallidayL W Powell
Jan 1, 1978·Scandinavian Journal of Gastroenterology·R G BateyA V Hoffbrand
Jan 1, 1978·American Journal of Hematology·A CeladaA Donath
Feb 1, 1977·Archives of Dermatology·J Chevrant-BretonB Ferrand
Jul 7, 1977·The New England Journal of Medicine·C Q EdwardsG E Cartwright
Feb 5, 1976·The New England Journal of Medicine·J R WandsL W Powell
Jan 1, 1973·The Biochemical Journal·R R CrichtonC F Bryce
Oct 1, 1973·Journal of Clinical Pathology·G O WaltersM Worwood
Dec 1, 1973·Journal of Clinical Pathology·R N MacSween, A R Scott
Jan 1, 1974·Clinical Genetics·R Saddi, J Feingold
Apr 1, 1969·Acta Medica Scandinavica·O LundvallP Lundin
Sep 25, 1980·Clinica Chimica Acta; International Journal of Clinical Chemistry·B M JonesA Jacobs
Jan 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J H CaskeyP A Seligman
May 1, 1982·Clinical Science·M WagstaffA Jacobs
Jul 1, 1982·British Journal of Haematology·T JenkinsA Laidler
Sep 1, 1982·American Journal of Hematology·C Q EdwardsJ P Kushner
Sep 1, 1981·British Journal of Haematology·H A Blacklock, M Meerkin
May 1, 1980·The Journal of Clinical Investigation·G E CartwrightD B Amos
Jul 1, 1980·Archives of Internal Medicine·A P Zimelman, A Miller
Jan 1, 1965·The American Journal of the Medical Sciences·R A MACDONALD

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Citations

Feb 14, 1998·American Journal of Hematology·C S ChimD Todd
Jan 1, 1994·Advances in Experimental Medicine and Biology·M WorwoodC Darke
Jan 1, 1987·Free Radical Research Communications·E Baysal, C Rice-Evans
Oct 28, 2006·Diabetes Research and Clinical Practice·Apostolos TsapasKonstantinos Paletas
Feb 1, 1986·Current Problems in Pediatrics·A D GarnicaO M Rennert

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