Iron and infection: the clinical evidence

Acta Paediatrica Scandinavica. Supplement
S J Oppenheimer

Abstract

Iron deficiency is prevalent in childhood in the developed and developing countries. Programs of presumptive therapy, mass supplementation and food fortification have been introduced in many countries. The unresolved debate over the interaction of iron and infection in the clinical setting prompts re-evaluation of these practices. Situations of iron overload are associated with increased susceptibility to certain infections, although the exact mechanisms may vary with the main pathology. Iron treatment has been associated with acute exacerbations of infection, in particular malaria. In most instances parenteral iron was used. In the neonate parenteral iron is associated with serious E. coli sepsis. In one country, with endemic malaria, parenteral iron was associated with increased rates of malaria and increased morbidity due to respiratory disease in infants. In contrast in non-malarious countries studies of oral iron supplementation have if anything shown a reduction in infectious morbidity. Methodological problems in the latter reports indicate the need for further controlled prospective studies with accurate morbidity recording if informed recommendations are to be made.

References

Mar 22, 1975·Lancet·M J MurrayM B Murray
Oct 1, 1977·Archives of Disease in Childhood·D M BecroftK Farmer
Oct 21, 1978·British Medical Journal·M J MurrayC J Murray
Oct 1, 1979·The American Journal of Clinical Nutrition·J D Cook, C A Finch
Apr 1, 1978·The Journal of Pediatrics·R T O'Brien
Oct 1, 1978·British Journal of Haematology·C HershkoE A Rachmilewitz
Jun 1, 1976·Archives of Disease in Childhood·K Farmer, D M Becroft
Apr 1, 1975·The Journal of Infectious Diseases·A R RabsonH J Koornhof
Feb 1, 1975·American Journal of Diseases of Children·J N Lukens
Jan 1, 1989·The American Journal of Tropical Medicine and Hygiene·P W HarveyK Forsyth
Aug 30, 1986·British Medical Journal·J H Brock
Jan 1, 1986·Transactions of the Royal Society of Tropical Medicine and Hygiene·S J OppenheimerR G Hendrickse
Jan 1, 1986·Transactions of the Royal Society of Tropical Medicine and Hygiene·S J OppenheimerO Bunari
May 1, 1988·JPEN. Journal of Parenteral and Enteral Nutrition·E Harju
Jan 1, 1987·The American Journal of Pediatric Hematology/oncology·D PotaznikM de Sousa
Jul 2, 1987·The New England Journal of Medicine·J J Goodill, J G Abuelo
Jan 1, 1986·Transactions of the Royal Society of Tropical Medicine and Hygiene·S J OppenheimerC Harrison
Jul 1, 1987·European Journal of Haematology·B CantinieauxP Fondu
Nov 1, 1987·Annals of Internal Medicine·D W WindusA Z Fenves
Oct 31, 1970·British Medical Journal·S ReddyH McFAarlane
Oct 23, 1969·The New England Journal of Medicine·M L Forman, E R Stiehm
Aug 1, 1973·The British Journal of Dermatology·J M Higgs, R S Wells
May 31, 1974·Science·E D Weinberg
Nov 1, 1973·British Journal of Haematology·K KanakakornA Jacobs
Sep 12, 1970·British Medical Journal·A B Byles, A D'sa
Apr 1, 1971·American Journal of Clinical Pathology·W M Buchanan
Oct 1, 1971·The Journal of Infectious Diseases·E D Weinberg
Apr 1, 1972·Archives of Disease in Childhood·D Burman
Aug 1, 1972·Journal of Pediatric Surgery·A J Eraklis, R M Filler
Sep 1, 1968·Journal of Clinical Pathology·J S CoxJ Reason
Feb 1, 1969·The Journal of Pediatrics·M E Miller
Jan 1, 1969·British Journal of Haematology·A Jacobs
Jan 1, 1966·American Journal of Diseases of Children·M B Andelman, B R Sered
Feb 1, 1984·Scandinavian Journal of Haematology·M AnuwatanakulchaiP Wasi
Aug 14, 1982·British Medical Journal·K MelbyS A Nordbø
Nov 1, 1981·Reviews of Infectious Diseases·J J Bullen
Feb 1, 1980·Annals of Tropical Medicine and Parasitology·S J Oppenheimer

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Citations

May 1, 1991·Acta paediatrica Scandinavica·D M Barry
Aug 1, 1996·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·V J Kumpf
Jun 12, 1999·Journal of Paediatrics and Child Health·S G KruskeD R Brewster
Jan 1, 1994·Transactions of the Royal Society of Tropical Medicine and Hygiene·S M Filteau, A M Tomkins
Jul 20, 1991·BMJ : British Medical Journal·D Stevens
Feb 1, 1993·The Proceedings of the Nutrition Society·S SouthonP M Finglas
Apr 1, 1994·Journal of Clinical Pathology·P HarrisonD Bareford
Aug 18, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·H P BeckC Menendez
Jan 1, 1991·Acta Paediatrica Scandinavica. Supplement·F Haschke, N Javaid
Apr 4, 2002·Journal of Pediatric Gastroenterology and Nutrition·Peter J AggettLawrence T Weaver
Sep 7, 2000·Transactions of the Royal Society of Tropical Medicine and Hygiene·R BeesleyS Parton
May 1, 1994·Antimicrobial Agents and Chemotherapy·G A Weinberg

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