PMID: 6112609Jun 13, 1981Paper

Iron and the sex difference in heart disease risk

Lancet
J L Sullivan

Abstract

Premenopausal women in affluent societies are protected from heart diseases which kill large numbers of men. The basis for this sex difference and the loss of protection with menopause is unknown. The hypothesis offered is that the greater incidence of heart diseases in men and postmenopausal women compared with the incidence in premenopausal women is due to higher levels of stored iron in these two groups. The hypothesis is supported by observations of (1) myocardial failure in iron strong disease, (2) accumulation of stored iron with age in men, and (3) accumulation of stored iron after menopause to levels found in men. In addition, the heart diseases of affluence are rare among impoverished peoples who are often iron deficient. The depletion of iron stores by regular phlebotomy could be the experimental system for testing this hypothesis, and a preventive therapy if the hypothesis is confirmed.

References

Sep 1, 1979·The American Journal of Cardiology·V J Vigorita, G M Hutchins
Nov 22, 1979·The New England Journal of Medicine·M B LeonA W Nienhuis

❮ Previous
Next ❯

Citations

Dec 1, 1996·Clinical Cardiology·D G Meyers
Mar 1, 1990·Human Nature : an Interdisciplinary Biosocial Perspective·S KentP Stuart-Macadam
Jan 1, 1997·Biological Trace Element Research·X JiaH Kayongo-Male
Dec 11, 2007·Annals of Hematology·Massimo FranchiniGiuseppe Lippi
Sep 4, 2013·Irish Journal of Medical Science·W J CashM E Callender
Sep 24, 2013·Current Atherosclerosis Reports·Emanuela LapiceOlga Vaccaro
Apr 17, 2010·Biological Trace Element Research·Farhana MazharFarooq Bashir
Oct 2, 2013·Indian Journal of Clinical Biochemistry : IJCB·Meghna Patel, D V S S Ramavataram
Mar 1, 1994·Atherosclerosis·J RegnströmA Hamsten
Apr 1, 1995·Obstetrics and Gynecology·R LuotoE M Rutanen
Apr 1, 1993·Mechanisms of Ageing and Development·H R MassieT R Williams
Jan 1, 1985·Molecular Aspects of Medicine·B Halliwell, J M Gutteridge
Feb 16, 1991·Lancet·J L Sullivan
Feb 1, 1983·Medical Hypotheses·W Martin
Jun 1, 1984·Medical Hypotheses·W Martin
Jan 1, 1984·Medical Hypotheses·W Martin
Dec 1, 1986·Medical Hypotheses·R J WeinbergE D Weinberg
Dec 1, 1992·Free Radical Biology & Medicine·J L Sullivan
Jul 1, 1994·Free Radical Biology & Medicine·J L Sullivan
Apr 13, 2005·International Journal of Cardiology·Erik LipsicFelix Zijlstra
Sep 8, 2001·The American Journal of Cardiology·A C PereiraJ E Krieger
Feb 28, 2002·AIDS Treatment News
May 30, 1998·Atherosclerosis·J E EichnerE Schechter
Jul 10, 2003·The Journal of Surgical Research·Ralph G DePalmaMark R Hall
Nov 5, 1999·International Journal of Cardiology·W C ManfroiM L Brizolara
Mar 23, 2000·Journal of Hepatology·L W PowellT R Yapp
Feb 19, 1998·Experimental Gerontology·D Harman
Dec 31, 2002·Journal of the American College of Cardiology·Hannes GaenzerGünter Weiss
Oct 15, 2003·Free Radical Biology & Medicine·Tomi-Pekka TuomainenJukka T Salonen
Dec 1, 1996·Journal of Clinical Epidemiology·J L Sullivan
Dec 1, 1996·Journal of Clinical Epidemiology·J L Sullivan
Feb 17, 2001·The Journal of Nutritional Biochemistry·J L. Sullivan
Jan 11, 2012·Public Health Nutrition·Meghan E OlesnevichMichele K Evans
Nov 13, 2001·British Journal of Haematology·T NeunteuflH Gisslinger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.