Iron-Based Metal-Organic Frameworks as a Theranostic Carrier for Local Tuberculosis Therapy

Pharmaceutical Research
Gabriela WyszogrodzkaPiotr Kulinowski

Abstract

The purpose of the study was initial evaluation of applicability of metal organic framework (MOF) Fe-MIL-101-NH2 as a theranostic carrier of antituberculous drug in terms of its functionality, i.e. drug loading, drug dissolution, magnetic resonance imaging (MRI) contrast and cytotoxic safety. Fe-MIL-101-NH2 was characterized using X-ray powder diffraction, FTIR spectrometry and scanning electron microscopy. The particle size analysis was determined using laser diffraction. Magnetic resonance relaxometry and MRI were carried out on phantoms of the MOF system suspended in polymer solution. Drug dissolution studies were conducted using Franz cells. For MOF cytotoxicity, commercially available fibroblasts L929 were cultured in Eagle's Minimum Essential Medium supplemented with 10% fetal bovine serum. MOF particles were loaded with 12% of isoniazid. The particle size (3.37-6.45 μm) depended on the micronization method used. The proposed drug delivery system can also serve as the MRI contrast agent. The drug dissolution showed extended release of isoniazid. MOF particles accumulated in the L929 fibroblast cytoplasmic area, suggesting MOF release the drug inside the cells. The cytotoxicity confirmed safety of MOF system. The applicati...Continue Reading

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Citations

Mar 4, 2020·International Journal of Molecular Sciences·Amlan ChakrabortyMagdalena Plebanski
Dec 28, 2019·Mini Reviews in Medicinal Chemistry·Xin ShenJianqiang Liu
Feb 20, 2021·ACS Applied Materials & Interfaces·Xianbin LiuMeiling Zhou

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fluorescence microscopy
X-ray

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Chem Office
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