Iron-based second-sphere contrast agents for magnetic resonance imaging: development of a model system and evaluation of iron (III) tris (tironate) complex in rats

Academic Radiology
J A DaviesJ Zeiss

Abstract

Iron(III) complexes have been developed as magnetic resonance (MR) contrast agents based on the use of ligands capable of providing coordinative saturation at iron and allowing the second-sphere hydrogen bonding of water molecules. Studies of solution-phase binding of a probe ion to a diamagnetic metal catecholate complex and molecular orbital calculations were performed. R1 values were determined. Toxicity studies of iron(III) tris(tironate) were conducted with rats. Excretion studies were performed by analysis of urine samples. MR measurements were made. Second-sphere coordination of a probe ion to a metal catecholate complex occurred in solution. Molecular orbital calculations suggested flexibility in design. Iron(III) tris (catecholate) complexes were shown to have high R1 values. Images of the kidneys and liver showed dose-dependent enhancement in T1-weighted images. The onset of toxicity was at approximately 0.30 mmol/kg. Urine analysis indicated essentially complete clearance (0.1-0.2 mmol/kg) within 24-48 hours. Interactions between water molecules and basic sites within a paramagnetic metal-ligand complex allow for application of suitable complexes as T1 agents.

Citations

Feb 3, 2007·Magma·Elisenda RodríguezMaria Luisa García-Martín
May 25, 2005·NMR in Biomedicine·Elisenda RodríguezCoral Sanfeliu
Dec 19, 2015·Small·Yiwen LiNathan C Gianneschi
Jun 29, 2013·ChemPlusChem·Jian-Xin YuRalph P Mason
Dec 22, 2020·European Journal of Medicinal Chemistry·Marzena Wyskocka-GajdaNikodem Kuźnik
Oct 17, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Duraiyarasu MaheshwaranRamasamy Mayilmurugan

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