Iron-Catalyzed Dehydration of Aldoximes to Nitriles Requiring Neither Other Reagents Nor Nitrile Media

Chemistry, an Asian Journal
Kengo HyodoKingo Uchida

Abstract

The dehydration of aldoximes is an environmentally benign reaction affording the desired nitrile and water as a by-product. However, most of the reported catalytic dehydration reactions of aldoximes require a solvent containing nitrile to synthesize the corresponding nitrile compounds. Inspired by recent reports on the enzymatic synthesis under nitrile-free conditions, we here describe that a simple iron salt catalyzes the dehydration of aldoximes requiring neither other reagents nor nitrile media. Our method can be applied to the one-pot synthesis of nitiriles from aldehydes.

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Citations

Jan 16, 2018·Chembiochem : a European Journal of Chemical Biology·Tobias BetkeHarald Gröger
May 6, 2020·Chemical Communications : Chem Comm·Wei ZhangJi-Chang Xiao
Dec 27, 2019·The Journal of Organic Chemistry·Yoshiyuki TakahashiMotoi Kawatsura
Oct 11, 2017·Chemical Reviews·Dmitrii S BolotinVadim Yu Kukushkin

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