Iron-catalyzed highly regio- and stereoselective conjugate addition of 2,3-allenoates with Grignard reagents

Journal of the American Chemical Society
Zhan LuShengming Ma


An efficient highly regio- and stereoselective iron-catalyzed conjugate addition of 2,3-allenoates with primary or secondary alkyl, phenyl, or vinyl Grignard reagents to synthesize multi-substituted beta,gamma-unsaturated enoates has been reported. The in situ formed magnesium dienolate may readily react with different electrophilic reagents to construct an allylic quaternary carbon at the alpha-position of the ester group.


Dec 9, 2004·Chemical Reviews·Carsten BolmLorenzo Zani
Jan 28, 2006·Angewandte Chemie·Bernd Plietker
Apr 21, 2006·Organic Letters·Lars K OttesenRoger Olsson
May 19, 2006·Organic Letters·Olga García Mancheño, Carsten Bolm
Oct 13, 2006·Journal of the American Chemical Society·Marco W BouwkampPaul J Chirik
Nov 23, 2006·Journal of the American Chemical Society·Donghui Zhang, Joseph M Ready
Feb 8, 2007·Journal of the American Chemical Society·Chuan-Ying LiLi-Xin Dai

❮ Previous
Next ❯


Sep 25, 2012·The Journal of Organic Chemistry·Niranjan Panda, Ashis Kumar Jena
Sep 16, 2011·Organic Letters·Guobi ChaiShengming Ma
Jul 10, 2009·Chemical Communications : Chem Comm·Haijun LiZhiping Li
Nov 19, 2009·Chemical Communications : Chem Comm·Benjamin D Sherry, Alois Fürstner
Mar 17, 2011·Chemical Communications : Chem Comm·Shichao Yu, Shengming Ma
Feb 9, 2016·Journal of the American Chemical Society·Jianxin DaiShengming Ma
Feb 25, 2015·Chemical Society Reviews·Ju Hyun KimSang-gi Lee
Jan 25, 2012·Angewandte Chemie·Shichao Yu, Shengming Ma
May 29, 2008·Angewandte Chemie·Mónica CarrilCarsten Bolm
Jan 16, 2009·Angewandte Chemie·Alois Fürstner
Jul 11, 2009·Angewandte Chemie·Katrin Marie DrillerMatthias Beller
Mar 19, 2013·Beilstein Journal of Organic Chemistry·Kei Murakami, Hideki Yorimitsu
Feb 24, 2015·Chemistry : a European Journal·Anna HedströmPer-Ola Norrby
Jun 6, 2014·Chemical Communications : Chem Comm·Bo ChenShengming Ma
Jul 26, 2013·Chemical Communications : Chem Comm·Shuang LuoZhang-Jie Shi
Nov 7, 2020·Chemical Communications : Chem Comm·Xin-Fang Duan
Dec 5, 2008·Organic Letters·Han YangGerald B Hammond
Sep 30, 2008·The Journal of Organic Chemistry·Xiao-Qing ZhuJin-Pei Cheng
Jul 1, 2008·Accounts of Chemical Research·Benjamin D Sherry, Alois Fürstner
Nov 5, 2008·The Journal of Organic Chemistry·Bo ChenShengming Ma
May 8, 2009·Organic Letters·Tongyu XuLiandi Wang
Mar 10, 2015·Chemical Reviews·Ingmar Bauer, Hans-Joachim Knölker

❮ Previous
Next ❯

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.