Iron-catalyzed, microwave-promoted, one-pot synthesis of 9-substituted xanthenes by a cascade benzylation-cyclization process

Organic Letters
Xiaobing XuYanzhong Li

Abstract

An efficient iron-catalyzed, microwave-promoted cascade benzylation-cyclization of phenols is reported. Benzyl acetates, benzyl bromides, and benzyl carbonates are suitable benzylating reagents. The reactions proceed to afford both 9-aryl and 9-alkyl xanthene derivatives in good to high yields using FeCl(3) as the catalyst under MW irradiation conditions.

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Citations

Feb 26, 2016·Organic Letters·Atsushi TaruiAkira Ando
Jan 13, 2011·Organic & Biomolecular Chemistry·Jingyu YangYanzhong Li
Jan 22, 2011·Organic & Biomolecular Chemistry·Esther BössMartin Klussmann
Dec 15, 2020·European Journal of Medicinal Chemistry·Miguel MaiaEmília Sousa
Mar 10, 2015·Chemical Reviews·Ingmar Bauer, Hans-Joachim Knölker

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