Iron deficiency alters expression of genes implicated in Alzheimer disease pathogenesis.

Brain Research
Erik S CarlsonMichael K Georgieff

Abstract

Neonatal brain iron deficiency occurs after insufficient maternal dietary iron intake, maternal hypertension, and maternal diabetes mellitus and results in short and long-term neurologic and behavioral deficits. Early iron deficiency affects the genomic profile of the developing hippocampus that persists despite iron repletion. The purpose of the present study was threefold: 1) quantitative PCR confirmation of our previous microarray results, demonstrating upregulation of a network of genes leading to beta-amyloid production and implicated in Alzheimer disease etiology in iron-deficient anemic rat pups at the time of hippocampal differentiation; 2) investigation of the potential contributions of iron deficiency anemia and iron treatment to this differential gene expression in the hippocampus; and 3) investigation of these genes over a developmental time course in a mouse model where iron deficiency is limited to hippocampus, is not accompanied by anemia and is not repletable. Quantitative PCR confirmed altered regulation in 6 of 7 Alzheimer-related genes (Apbb1, C1qa, Clu, App, Cst3, Fn1, Htatip) in iron-deficient rats relative to iron-sufficient controls at P15. Comparison of untreated to treated iron-deficient animals at this...Continue Reading

References

Jul 1, 1992·The Journal of Pediatrics·C D PetryM K Georgieff
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·C D SmithW R Markesbery
Jan 1, 1988·Alzheimer Disease and Associated Disorders·D E SchmechelA D Roses
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D H BingR O Hynes
Jul 11, 1996·Nature·M A SmithN Kowall
Sep 2, 1997·Proceedings of the National Academy of Sciences of the United States of America·M A SmithG Perry
Mar 21, 2000·Genesis : the Journal of Genetics and Development·I Dragatsis, S Zeitlin
Jan 26, 2002·British Medical Bulletin·S E Ozanne
Oct 9, 2002·Trends in Endocrinology and Metabolism : TEM·David J P Barker
Nov 19, 2002·Neuroscience·S KesavapanyD M McLoughlin
Feb 18, 2004·Developmental Neuroscience·Lyric A JorgensonMichael K Georgieff
May 25, 2004·Pediatric Research·Ashajyothi M SiddappaRaye-Ann Deregnier
Jun 29, 2004·Nature Neuroscience·Ian C G WeaverMichael J Meaney
Apr 26, 2005·The Journal of Clinical Investigation·Hiromi GunshinNancy C Andrews
Oct 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·Korry J Hintze, Elizabeth C Theil
Jul 20, 2006·Annual Review of Nutrition·Steven H Zeisel
Nov 15, 2006·Seminars in Pediatric Neurology·Betsy Lozoff, Michael K Georgieff
Dec 13, 2006·Seminars in Fetal & Neonatal Medicine·Raghavendra Rao, Michael K Georgieff
Jan 11, 2007·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Elizabeth C Theil
Jun 27, 2007·Behavioral Neuroscience·Adam T SchmidtMichael K Georgieff
Mar 21, 2008·Neurobiology of Disease·Sarah J E Wong-GoodrichChristina L Williams

❮ Previous
Next ❯

Citations

Aug 4, 2011·The Journal of Physiological Sciences : JPS·Fuminori KawanoYoshinobu Ohira
Mar 11, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·George BartzokisJames R Connor
Nov 10, 2011·American Journal of Physiology. Endocrinology and Metabolism·Phu V TranMichael K Georgieff
Oct 19, 2010·International Journal of Alzheimer's Disease·L ChouliarasB P F Rutten
Feb 15, 2011·Toxicology and Applied Pharmacology·Andrew D MonnotWei Zheng
Oct 22, 2008·Brain Research·Christina L Williams
May 18, 2016·Mitochondrion·Freya ShephardLisa Chakrabarti
Apr 20, 2010·The Australian and New Zealand Journal of Psychiatry·Felice N JackaJoanne W Williams
Sep 2, 2020·Nutrients·Tanja Grubić Kezele, Božena Ćurko-Cofek
Nov 23, 2017·Frontiers in Medicine·Claudie HooperUNKNOWN MAPT/DSA Study Group
Aug 21, 2020·Learning & Memory·Jack T Rogers, Catherine M Cahill
Jun 2, 2012·Expert Review of Neurotherapeutics·Paul M Thompson, Neda Jahanshad
Feb 25, 2020·Free Radical Biology & Medicine·Andrew J GhioMichael C Madden
Jul 27, 2021·Behavioural Neurology·Yao-Chin WangWoon-Man Kung

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Polyendocrinopathies

Autoimmune polyendocrinopathies, also called polyglandular autoimmune syndromes (PGASs), or polyendocrine autoimmune syndromes(PASs), are a heterogeneous group of rare diseases characterized by autoimmune activity against more than one endocrine organ, although non-endocrine organs can be affected. Discover the latest research on autoimmune polyendocrinopathies here.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Autoimmune Polyendocrine Syndromes

This feed focuses on a rare genetic condition called Autoimmune Polyendocrine Syndromes, which are characterized by autoantibodies against multiple endocrine organs. This can lead to Type I Diabetes.

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.

Alzheimer's Disease: Animal Models

Alzheimer's disease is a neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.