PMID: 8590632Oct 1, 1995Paper

Iron deprivation results in an increase in p53 expression

Biological Chemistry Hoppe-Seyler
K FukuchiK Gomi

Abstract

Deferoxamine (DFO)-induced iron deprivation caused an increase in p53 expression in ML-1 and Raji cells. In ML-1 cells, with express wild type p53, p53 protein levels were transiently increased 6 h after addition of 10(-4)M DFO. In Raji cells, which carry a mutant p53 allele, p53 increased 6 h after addition of 10(-4)M DFO and remained elevated for 24 h. Growth inhibition was observed in both cell types 6 h after addition of 10(-4)M DFO. In both cells, p53 mRNA levels did not increase following incubation with DFO, suggesting that increased p53 expression is the result of a post-transcriptional mechanism. Although increases in wild type p53 protein in ML-1 cells resulted in increases in a p53 target gene, p21cipl/wafl/sdil, this effect was not observed in Raji cells which express a mutant p53 protein.

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Citations

Aug 25, 2018·Metallomics : Integrated Biometal Science·Jian WangPing Shi
Aug 26, 1998·Leukemia & Lymphoma·M TormoG Lopez-Berestein
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