Iron Exposure and the Cellular Mechanisms Linked to Neuron Degeneration in Adult Mice

Cells
Lin-Bo LiChuang Guo

Abstract

Although the causal relationship between Alzheimer's disease (AD) and iron overload remains unclear, iron dyshomeostasis or improper transport mechanisms are speculated to lead to the accumulation of this neurotoxic metal in the hippocampal formation and other cerebral areas related to neurodegenerative diseases, resulting in the formation of reactive oxygen species (ROS) and, ultimately, cell death. In this study, exposure to high dietary iron (HDI) revealed no significant difference in the number of iron-positive cells and iron content in the cortex and hippocampal region between wild-type (WT) and APP/PS1 mice; however, compared with the control mice, the HDI-treated mice exhibited upregulated divalent metal transporter 1 (DMT1) and ferroportin (Fpn) expression, and downregulated transferrin receptor (TFR) expression. Importantly, we confirmed that there were significantly fewer NeuN-positive neurons in both APP/PS1 and WT mice given HDI, than in the respective controls. Moreover, this iron-induced neuron loss may involve increased ROS and oxidative mitochondria dysfunction, decreased DNA repair, and exacerbated apoptosis and autophagy. Although HDI administration might trigger protective antioxidant, anti-apoptosis, and aut...Continue Reading

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Citations

May 7, 2020·Frontiers in Neuroscience·Xiaohua Song, Dingxin Long
Nov 26, 2020·International Journal of Molecular Sciences·Cadiele Oliana ReichertSérgio Paulo Bydlowski
Nov 6, 2020·Free Radical Biology & Medicine·Shuangwen LiZhongming Wu
Apr 3, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yitian SunGuoxiong Li
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Mar 2, 2021·Journal of Alzheimer's Disease : JAD·Guimei ZhangLi Sun
May 26, 2021·The Science of the Total Environment·Bingyun LiYanshu Li
Jun 29, 2021·Frontiers in Cell and Developmental Biology·Xun WuChengming Fan
Aug 10, 2021·Frontiers in Cardiovascular Medicine·Huilin HuLiang Shen
Aug 25, 2021·Yonsei Medical Journal·Qingxin SongXiaosong Zhu

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Methods Mentioned

BETA
MDA
protein assay

Software Mentioned

Graphpad prism
Quantity One
ImageJ

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