Iron Homeostasis in Health and Disease.

International Journal of Molecular Sciences
Raffaella Gozzelino, Paolo Arosio

Abstract

Iron is required for the survival of most organisms, including bacteria, plants, and humans. Its homeostasis in mammals must be fine-tuned to avoid iron deficiency with a reduced oxygen transport and diminished activity of Fe-dependent enzymes, and also iron excess that may catalyze the formation of highly reactive hydroxyl radicals, oxidative stress, and programmed cell death. The advance in understanding the main players and mechanisms involved in iron regulation significantly improved since the discovery of genes responsible for hemochromatosis, the IRE/IRPs machinery, and the hepcidin-ferroportin axis. This review provides an update on the molecular mechanisms regulating cellular and systemic Fe homeostasis and their roles in pathophysiologic conditions that involve alterations of iron metabolism, and provides novel therapeutic strategies to prevent the deleterious effect of its deficiency/overload.

References

Mar 1, 1991·Archives of Biochemistry and Biophysics·M DizdarogluE Gajewski
Jun 1, 1990·American Heart Journal·R B Lauffer
May 1, 1989·American Heart Journal·J L Sullivan
Jun 13, 1981·Lancet·J L Sullivan
Mar 1, 1994·Epidemiology·H I MorrisonD T Wigle
Jun 9, 2001·Nutrition Reviews·R L Nelson
May 3, 2002·Blood·Frank M Torti, Suzy V Torti
Feb 6, 2004·Blood Cells, Molecules & Diseases·Antonello Pietrangelo
Mar 24, 2004·Annals of Epidemiology·Tiejian WuEllen Smit
Mar 27, 2004·The Journal of Biological Chemistry·Partha KrishnamurthyJohn D Schuetz
Mar 31, 2004·The American Journal of Medicine·Kevin KnightLodovico Balducci
Aug 2, 2005·Cell Metabolism·Adriana DonovanNancy C Andrews
Oct 4, 2006·Annual Review of Physiology·Nancy C Andrews, Paul J Schmidt
May 23, 2008·Proceedings of the National Academy of Sciences of the United States of America·Anoop K SendamaraiC Martin Lawrence
Apr 23, 2009·Blood·Augustine FernandesElizabeta Nemeth
Aug 5, 2009·BMC Cardiovascular Disorders·Andy MenkeEliseo Guallar
Jan 13, 2010·Molecular Cell·Andrew J Deans, Stephen C West
Jun 15, 2010·Gastroenterology·Antonello Pietrangelo
Oct 15, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M DicatoM Diederich
Dec 15, 2010·Advances in Experimental Medicine and Biology·Raffaella Gozzelino, Miguel P Soares
Mar 3, 2011·Cancer Research·Suzy V Torti, Frank M Torti
May 17, 2011·Nature Medicine·Silvia PortugalMaria M Mota
Jan 27, 2012·Free Radical Research·Miral Dizdaroglu, Pawel Jaruga
Feb 7, 2012·Biochimica Et Biophysica Acta·Tomas Ganz, Elizabeta Nemeth
May 11, 2012·Indian Heart Journal·M P HolayS D Suryawanshi
May 16, 2012·Frontiers in Pharmacology·Rasmus LarsenRaffaella Gozzelino
Nov 10, 2012·Science·Hal Drakesmith, Andrew M Prentice
Nov 29, 2012·The Journal of Clinical Investigation·Deborah ChiabrandoEmanuela Tolosano
Apr 18, 2013·PloS One·Lorena Fernandes ArrudaEgle Machado de Almeida Siqueira
Apr 19, 2013·Nature Reviews. Cancer·Suzy V Torti, Frank M Torti
Oct 16, 2013·Antioxidants & Redox Signaling·Raffaella Gozzelino, Miguel P Soares
Dec 7, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R OrlandiI Bongarzone
Jan 16, 2014·Frontiers in Pharmacology·Zvi Ioav CabantchikDavid Devos
Mar 4, 2014·World Journal of Gastroenterology : WJG·Manuel MuñozMichael Auerbach
Mar 7, 2014·Frontiers in Pharmacology·Guofen Gao, Yan-Zhong Chang
Mar 13, 2014·Frontiers in Pharmacology·Jorge P PintoGraça Porto
Mar 13, 2014·Frontiers in Pharmacology·Elena GammellaGaetano Cairo
Mar 14, 2014·Frontiers in Pharmacology·Grazia Isaya
Mar 19, 2014·Frontiers in Pharmacology·Lu ZhaoFudi Wang
Mar 19, 2014·Frontiers in Pharmacology·Christal A Worthen, Caroline A Enns

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Citations

Mar 16, 2017·Thyroid : Official Journal of the American Thyroid Association·Shiqian Hu, Margaret P Rayman
May 18, 2017·Acta Haematologica·Cadiele Oliana ReichertCelso Spada
Mar 7, 2017·Journal of the International Society of Sports Nutrition·Anna Skarpańska-StejnbornDonata Woitas-Ślubowska
Dec 13, 2016·Biochimica Et Biophysica Acta. Molecular Cell Research·Rawan EidMichael T Greenwood
Dec 19, 2016·Molecular and Biochemical Parasitology·Amir ZaidiVahab Ali
Dec 16, 2017·Journal of Cellular Physiology·Wan-Jing CenJian-Wei Jiang
Apr 5, 2018·Journal of Experimental & Clinical Cancer Research : CR·Maida De BortoliItalia Bongarzone
Dec 14, 2017·Assay and Drug Development Technologies·Hermann A M Mucke
May 26, 2016·Parasitology·Qinwang NiuJianping Chen
Sep 14, 2017·Scientific Reports·Daniele ZanellaGiovanni Bernardini
Sep 1, 2019·Medicinal Research Reviews·Zhong-Ming Qian, Ya Ke
Jan 9, 2020·Biological Trace Element Research·XueJie LiuXueLi Gao
Aug 7, 2020·Journal of Animal Science·Jing ZhouYulong Yin
Jun 24, 2017·The Journal of Biological Chemistry·Yong XueSiavash K Kurdistani
Jul 21, 2017·Scientific Reports·Inês B SantarinoOtília V Vieira
Jul 18, 2018·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Alessia CarocciGiuseppe Genchi
Jul 22, 2018·Biological Trace Element Research·Wan MaHuahua Du
Jul 20, 2017·The Journal of Pathology·Annalisa CapobiancoPatrizia Rovere-Querini
Jun 8, 2018·Nutrients·Yutian PuHuahua Du
May 3, 2019·Oxidative Medicine and Cellular Longevity·Alessandra BolottaCinzia Zucchini
Nov 14, 2019·International Journal of Environmental Research and Public Health·Sehar IqbalCem Ekmekcioglu
Jan 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yongming LiRui Zhao
Nov 2, 2017·Frontiers in Physiology·Jean-Christophe DescheminSophie Vaulont
Jul 22, 2019·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Nathan F DentonKatherine E Pinnick
May 6, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Saideh FakharzadehAbbas Basiri
Feb 25, 2020·Oxidative Medicine and Cellular Longevity·Alexandra BarboutiPanagiotis Kanavaros

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Methods Mentioned

BETA
X-ray
coronary artery bypass

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