Iron homeostasis in the lung.

Biological Research
Andrew J GhioM D Garrick

Abstract

Iron is essential for many aspects of cellular function. However, it also can generate oxygen-based free radicals that result in injury to biological molecules. For this reason, iron acquisition and distribution are tightly regulated. Constant exposure to the atmosphere results in significant exposure of the lungs to catalytically active iron. The lungs have a mechanism for detoxification to prevent associated generation of oxidative stress. Those same proteins that participate in iron uptake in the gut are also employed in the lung, to transport iron intracellularly and sequester it in an inactive form within ferritin. The release of metal is expedited (as transferrin and ferritin) from lung tissue to the respiratory lining fluid for clearance by the mucocilliary pathway or to the reticuloendothelial system for long-term storage. This pathway is likely to be the major method for the control of oxidative stress presented to the respiratory tract.

Citations

Mar 26, 2011·Genes & Nutrition·Michael D Garrick
Jun 30, 2012·PloS One·Karolina BenesovaMartina U Muckenthaler
Jul 24, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Kyong-Son MinKeiichi Tanaka
Feb 24, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christopher J ChoiAnumantha G Kanthasamy
Aug 9, 2011·Pulmonary Pharmacology & Therapeutics·Sven van EijlNanne Bloksma
Aug 15, 2009·Toxicology and Applied Pharmacology·J Grace WallenbornUrmila P Kodavanti
Apr 7, 2009·Biochimica Et Biophysica Acta·Michael D Garrick, Laura M Garrick
Nov 19, 2008·The Journal of Allergy and Clinical Immunology·Gyu-Young HurHae-Sim Park
Apr 8, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Dag G EllingsenYngvar Thomassen
Jun 13, 2015·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Mihaela RaduAnca Dinischiotu
Nov 28, 2012·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Andrew J GhioMarianne S Muhlebach
Feb 20, 2008·Current Topics in Developmental Biology·Deepa Manwani, James J Bieker
May 13, 2017·The International Journal of Biochemistry & Cell Biology·Md Khadem AliJay C Horvat
Dec 7, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Anna L LaganGregory J Quinlan
Sep 17, 2014·The Annals of Occupational Hygiene·Swaantje CasjensBeate Pesch
Dec 5, 2018·Frontiers in Molecular Biosciences·Harry G ShermanFrankie J Rawson
Aug 25, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·D W ReidI L Lamont
Jun 1, 2021·Toxicology Mechanisms and Methods·Julio César Córdoba-AdayaKeila Isaac-Olivé
Sep 29, 2019·Environmental Science & Technology·Ting FangManabu Shiraiwa

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