PMID: 8951425Dec 1, 1996Paper

Iron (II) ions induced oxidation of ascorbic acid and glucose

Free Radical Research
A MlakarG Spiteller

Abstract

Lipid peroxidation (LPO) of polyunsaturated fatty acids (PUFAs) is suspected to be involved in the generation of chronic diseases. A model reaction for LPO is the air oxidation of PUFAs initiated by Fe2+ and ascorbic acid. In the course of such model reactions glycolaldehyde (GLA) was detected as main aldehydic product. Since it is difficult to explain the generat on of GLA by oxidation of PUFAs, it was suspected that GLA might be derived by oxidation of ascorbic acid. This assumption was verified by treatment of ascorbic acid with Fe2+. Produced aldehydic compounds were trapped by addition of pentafluorobenzylhydroxylamine hydrochloride (PFBHA-HCl), trimethylsilylated and finally identified by gas chromatography/mass spectronetry (GC/MS). Oxidation of ascorbic acid with O2 in presence of iron ions produced not only glycolaldehyde (GLA), but also glyceraldehyde (GA), dihydroxyacetone (DA) and formaldehyde. Glyoxal (GO) and malondialdehyde (MDA) were detected as trace compounds. The yield of the aldehydic compounds was increased by addition of lipid hydroperoxides (LOOH) or H2O2. The buffer influenced the reaction considerably: Iron ions react with Tris buffer by producing dihydroxyacetone (DA). Since ascorbic acid is present in...Continue Reading

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Citations

Oct 6, 2000·Biochimica Et Biophysica Acta·C SadyR H Nagaraj
Oct 11, 2002·Free Radical Biology & Medicine·Paola OteroBartolomé Bonet
Jan 1, 1996·Free Radical Biology & Medicine·G Spiteller
Jun 25, 1999·Free Radical Biology & Medicine·N MistryJ Lunec
Dec 17, 2009·The British Journal of Nutrition·Ruth J BevanJoseph Lunec
Nov 10, 2009·Bioscience, Biotechnology, and Biochemistry·Yuri NomiChuyen Van Nguyen
May 23, 2014·Diabetes/metabolism Research and Reviews·Randhir SinghRakesh Gollen
May 16, 2006·Carbohydrate Research·Paola ManiniMarco d'Ischia
Sep 11, 2004·Biochemical and Biophysical Research Communications·Hiroyoshi IwataMasayoshi Sawamura
Sep 4, 2004·Biochemical Pharmacology·Nandita Shangari, Peter J O'Brien
Oct 22, 2003·Archives of Biochemistry and Biophysics·Vincent M Monnier
Apr 21, 2006·Diabetes Research and Clinical Practice·Tomokazu OyamaKohji Shirai
Jul 9, 2017·Chemistry : a European Journal·Zhen Yu, James A Cowan
Feb 21, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Nalini MistryJoseph Lunec
Oct 11, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marina DulićMarijana Zovko Končić
Nov 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Plamen MomchevMarijana Zovko Končić
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lejsa JakupovićMarijana Zovko Končić
Oct 6, 2020·Journal of the American Chemical Society·Steve D KnutsonJennifer M Heemstra
Oct 23, 2020·Chemical Reviews·Christopher P HopperBinghe Wang
Apr 11, 2021·Nitric Oxide : Biology and Chemistry·Christopher P HopperJakob Wollborn
Jul 18, 2021·Microbiological Research·Jintana Duang-NkernSkorn Mongkolsuk

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