Iron Imports. VI. HFE and regulation of intestinal iron absorption

American Journal of Physiology. Gastrointestinal and Liver Physiology
Robert E Fleming, R S Britton

Abstract

The majority of clinical cases of iron overload is caused by mutations in the HFE gene. However, the role that HFE plays in the physiology of intestinal iron absorption remains enigmatic. Two major models have been proposed: 1) HFE exerts its effects on iron homeostasis indirectly, by modulating the expression of hepcidin; and 2) HFE exerts its effects directly, by changing the iron status (and therefore the iron absorptive activity) of intestinal enterocytes. The first model places the primary role of HFE in the liver (hepatocytes and/or Kupffer cells). The second model places the primary role in the duodenum (crypt cells or villus enterocytes). These models are not mutually exclusive, and it is possible that HFE influences the iron status in each of these cell populations, leading to cell type-specific downstream effects on intestinal iron absorption and body iron distribution.

References

Feb 1, 1994·Immunology Letters·M de SousaG Porto
Nov 1, 1996·Journal of Gastroenterology and Hepatology·G J Anderson
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·S ParkkilaW S Sly
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·A WaheedW S Sly
Sep 15, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·D M FrazerG J Anderson
Apr 12, 2002·Proceedings of the National Academy of Sciences of the United States of America·Debbie TrinderEvan H Morgan
Nov 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hal DrakesmithAlain R M Townsend
Jan 28, 2003·Blood Cells, Molecules & Diseases·Kaashif A AhmadRobert E Fleming
May 10, 2003·Blood Cells, Molecules & Diseases·David M Frazer, Gregory J Anderson
Aug 21, 2003·Journal of Hepatology·Petra HolmströmGösta Eggertsen
Dec 16, 2003·Proceedings of the National Academy of Sciences of the United States of America·Shunji TomatsuWilliam S Sly
Dec 24, 2003·PLoS Biology·Anthony M GiannettiPamela J Björkman
Mar 27, 2004·The Journal of Biological Chemistry·Paige S Davies, Caroline A Enns
Apr 2, 2004·The Journal of Biological Chemistry·Anthony M Giannetti, Pamela J Björkman
Jun 3, 2004·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Susanne LudwiczekGuenter Weiss
Oct 7, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Catherine MuraClaude Férec
Sep 15, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·David M Frazer, Gregory J Anderson
Jan 13, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Tomas Ganz, Elizabeta Nemeth

❮ Previous
Next ❯

Citations

May 3, 2007·Pflügers Archiv : European journal of physiology·Phillip S Oates
Nov 22, 2012·Investigative Ophthalmology & Visual Science·Jaya P Gnana-PrakasamVadivel Ganapathy
Apr 24, 2009·BMC Neuroscience·Milla M HänninenSeppo Parkkila
Jul 19, 2012·World Journal of Gastroenterology : WJG·Alan B R ThomsonHugh Freeman
Jun 13, 2014·Blood Cells, Molecules & Diseases·Maria Carmela PadulaAttilio Olivieri
May 23, 2012·Expert Opinion on Drug Discovery·Sheli R RadoshitzkySina Bavari
Oct 13, 2009·Blood Cells, Molecules & Diseases·Maja ChloupkováCaroline A Enns
Apr 7, 2009·Biochimica Et Biophysica Acta·Michael D Garrick, Laura M Garrick
Nov 30, 2007·Free Radical Biology & Medicine·Jorge P PintoMaria de Sousa
Nov 15, 2006·Seminars in Pediatric Neurology·Tracey A Rouault, Sharon Cooperman
Apr 1, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Bruce R BaconUNKNOWN American Association for the Study of Liver Diseases
Apr 22, 2010·IUBMB Life·Jaya P Gnana-PrakasamVadivel Ganapathy
Jun 6, 2015·Experimental Physiology·Gisela GiorgiMarta Elena Roque
Aug 29, 2006·Journal of Theoretical Biology·Bert J Lao, Daniel T Kamei
Aug 3, 2011·Current Opinion in Microbiology·Hyeryun ChoeMichael Farzan
Apr 7, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Magnus Domellöf
Apr 10, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Nadeem SheikhGiuliano Ramadori
May 21, 2020·International Journal of Molecular Sciences·Raffaela RamettaPaola Dongiovanni
Oct 28, 2017·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Suad AlFadhliRasheeba Nizam
Jan 21, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Rebecca E GraffA Heather Eliassen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Seminars in Liver Disease
Robert E FlemingB R Bacon
American Journal of Physiology. Gastrointestinal and Liver Physiology
T Ganz, Elizabeta Nemeth
American Journal of Physiology. Gastrointestinal and Liver Physiology
Bryan Mackenzie, Michael D Garrick
American Journal of Physiology. Gastrointestinal and Liver Physiology
Marianne Wessling-Resnick
American Journal of Physiology. Gastrointestinal and Liver Physiology
Yuxiang MaJonathan Glass
© 2021 Meta ULC. All rights reserved