Aug 10, 2017

Iron in neurodegenerative disorders: being in the wrong place at the wrong time?

Reviews in the Neurosciences
Sotirios Apostolakis, Anna-Maria Kypraiou


Brain iron deposits have been reported consistently in imaging and histologic examinations of patients with neurodegenerative disorders. While the origins of this finding have not been clarified yet, it is speculated that impaired iron homeostasis or deficient transport mechanisms result in the accumulation of this highly toxic metal ultimately leading to formation of reactive oxygen species and cell death. On the other hand, there are also those who support that iron is just an incidental finding, a by product of neuronal loss. A literature review has been performed in order to present the key findings in support of the iron hypothesis of neurodegeneration, as well as to identify conditions causing or resulting from iron overload and compare and contrast their features with the most prominent neurodegenerative disorders. There is an abundance of experimental and observational findings in support of the hypothesis in question; however, as neurodegeneration is a rare incident of commonly encountered iron-associated disorders of the nervous system, and this metal is found in non-neurodegenerative disorders as well, it is possible that iron is the result or even an incidental finding in neurodegeneration. Understanding the underly...Continue Reading

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Mentioned in this Paper

Familial Alzheimer Disease (FAD)
Jaundice, Obstructive
Iron Chelating Agents
Histology Procedure
Cell Injury
Iron Metabolism Disorders
Question (Inquiry)
Neurodegenerative Disorders Pathway

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