PMID: 1194835Oct 1, 1975Paper

Iron incorporation and haemoglobin synthesis in erythropoietic cells during the ontogenesis of the mouse

Journal of Embryology and Experimental Morphology
M SchalekampJ Paul

Abstract

Iron incorporation (59Fe) into erythropoietic cells from adult and foetal (11- to 15-day) peripheral blood and from foetal (12- to 15-day) livers has been investigated. Ion-exchange chromatography of haemolysates from such cells revealed two groups of 59Fe-containing proteins. The first group (X-fraction) was eluted from CMC-columns in the void volume and was highest in lysates of immature erythropoietic cells. This fraction contained a radiolabelled haemprotein of high molecular weight as well as other 59Fe-containing proteins. The haemprotein does not appear to be related to haemoglobin. The second group consisted of haemoglobins. One major (A1) and two minor (A2 and A3) haemoglobins were found in adult peripheral blood. In foetal liver lysates two major (F1 and A1) and two minor (F2 and A3) haemoglobins were present. The relative proportion of the major haemoglobins changed during development. Haemoglobin F1 was highest in the more mature livers. F1 proved to be different from A1 by chromatographic behaviour, in polypeptide chain composition and in fingerprints. A unique foetal polypeptide chain, intermediate in electrophoretic behaviour between the adult alpha- and beta-chain, was identified. In young foetal peripheral bloo...Continue Reading

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