Iron-induced changes in nitric oxide and superoxide radical generation in rat liver after lindane or thyroid hormone treatment

Toxicology Letters
Pamela CornejoVirginia Fernández

Abstract

The involvement of cytosolic nitric oxide (NO) and mitochondrial superoxide radical (O2(.-)) production was evaluated as a mechanism triggering liver oxidative stress in lindane (40 mg/kg) or L-3,3',5-triiodothyronine (T3, 0.1 mg/kg for 2 consecutive days) treated animals (male Sprague-Dawley rats) subjected to iron overload (200 mg/kg). Lindane and iron led to 504 and 210% increases in the content of hepatic protein carbonyls as an index of oxidative stress, with a 706% enhancement being produced by their combined administration. T3 did not alter this parameter, whereas iron overload increased the content of protein carbonyls by 116% in hyperthyroid rats. Lindane increased NO generation by 106% without changes in generation of O2(.-), whereas iron enhanced both parameters by 109 and 80% over control values, respectively, with a net 33 and 46% decrease, respectively, being elicited by the combined treatment related to iron overload alone. Hyperthyroidism increased liver NO (69%) and O2(.-) (110%) generation compared to controls, effects that were either synergistically augmented or suppressed by iron overload, respectively. The in vitro addition of iron (1 micromol/mg protein) to liver cytosolic fractions from euthyroid (97%) a...Continue Reading

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Citations

Jul 26, 2012·Angiogenesis·Nicolas ClereSébastien Faure
Mar 31, 2004·Molecular Aspects of Medicine·Monica GalleanoSusana Puntarulo
Jun 2, 2005·Nitric Oxide : Biology and Chemistry·Pamela CornejoVirginia Fernández
May 22, 2003·Free Radical Biology & Medicine·Akira I HidaShigeru Okada
Oct 20, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kan SaitoRyozo Nagai
May 9, 2012·World Journal of Hepatology·Virginia FernándezLuis A Videla
Jun 3, 2015·Pakistan Journal of Biological Sciences : PJBS·Samy Ali Hussein AzizaSoheir Kamal El-Shall
Dec 21, 2012·Cellular and Molecular Life Sciences : CMLS·Paola VendittiSergio Di Meo
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Aug 17, 2005·Molecular Aspects of Medicine·Susana Puntarulo
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Oct 19, 2011·Toxicologic Pathology·Ivan RousseauSusana Puntarulo
Nov 3, 2009·Human & Experimental Toxicology·T RadosavljevićO Stanojlović

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