Iron metabolism and the polycystic ovary syndrome

Trends in Endocrinology and Metabolism : TEM
Héctor F Escobar-Morreale

Abstract

The polycystic ovary syndrome (PCOS) is associated with insulin resistance and abnormal glucose tolerance. Iron overload may lead also to insulin resistance and diabetes. Serum ferritin levels are increased in PCOS, especially when glucose tolerance is abnormal, suggesting mild iron overload. Factors contributing to potential iron overload in PCOS include the iron sparing effect of chronic menstrual dysfunction, insulin resistance, and a decrease in hepcidin leading to increased iron absorption. Enhancement of erythropoiesis by androgen excess is unlikely, because soluble transferrin receptor levels are not increased in PCOS. Future venues of research should address the long-term effects of PCOS treatment on iron overload and, conversely, the possible effects of iron lowering strategies on the glucose tolerance of patients with PCOS.

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Citations

Oct 12, 2014·Current Hypertension Reports·Manuel Luque-Ramírez, Héctor F Escobar-Morreale
Oct 4, 2013·Expert Review of Proteomics·María Insenser, Héctor F Escobar-Morreale
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Oct 6, 2018·Expert Opinion on Pharmacotherapy·Andrés E Ortiz-FloresHéctor F Escobar-Morreale
May 18, 2019·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Raphael Enrique TiongcoMaria Ruth Pineda-Cortel
May 31, 2014·The Journal of Clinical Endocrinology and Metabolism·Stefano PalombaFulvio Zullo
May 8, 2018·Analytical Cellular Pathology (Amsterdam)·Ulises UrzuaNicole Hernandez
Jan 20, 2021·The Journal of Clinical Endocrinology and Metabolism·Andrés E Ortiz-FloresManuel Luque-Ramírez
Mar 23, 2021·Frontiers in Physiology·Renfeng Xu, Zhengchao Wang
Jul 3, 2021·Nutrients·Kamila Pokorska-NiewiadaMałgorzata Szczuko

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