Iron mobilization using chelation and phlebotomy

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
Trond Peder FlatenGeorge J Kontoghiorghes

Abstract

Knowledge of the basic mechanisms involved in iron metabolism has increased greatly in recent years, improving our ability to deal with the huge global public health problems of iron deficiency and overload. Several million people worldwide suffer iron overload with serious clinical implications. Iron overload has many different causes, both genetic and environmental. The two most common iron overload disorders are hereditary haemochromatosis and transfusional siderosis, which occurs in thalassaemias and other refractory anaemias. The two most important treatment options for iron overload are phlebotomy and chelation. Phlebotomy is the initial treatment of choice in haemochromatosis, while chelation is a mainstay in the treatment of transfusional siderosis. The classical iron chelator is deferoxamine (Desferal), but due to poor gastrointestinal absorption it has to be administered intravenously or subcutaneously, mostly on a daily basis. Thus, there is an obvious need to find and develop new effective iron chelators for oral use. In later years, particularly two such oral iron chelators have shown promise and have been approved for clinical use, namely deferiprone (Ferriprox) and deferasirox (Exjade). Combined subcutaneous (def...Continue Reading

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Citations

Nov 30, 2013·Biological Trace Element Research·Cecilie DahlUNKNOWN Norwegian Epidemiologic Osteoporosis Study (NOREPOS) Core Research Group
Sep 24, 2013·The American Journal of Medicine·Cynthia E CherfaneKyle E Brown
Jun 7, 2013·Journal of Clinical Pharmacology·Matthew R BedfordChris Tselepis
May 7, 2016·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Ole Andersen, Jan Aaseth
Feb 5, 2013·Free Radical Biology & Medicine·Orly WeinrebTamar Amit
Jun 9, 2016·Journal of Clinical Apheresis·Dorothea BrücklAbdulgabar Salama
Aug 28, 2013·Food & Function·Karadka Ramdas ThilakchandManjeshwar Shrinath Baliga
Oct 24, 2018·Pharmaceuticals·Marco T Nuñez, Pedro Chana-Cuevas
Sep 22, 2020·Macromolecular Bioscience·Ondřej GroborzMartin Hrubý
Feb 23, 2020·Vox Sanguinis·Catherine R MurphreeJoseph J Shatzel

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