Iron modulates the alpha chain of fibrinogen

Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Vance G Nielsen, Wayne K Jacobsen

Abstract

Iron-bound fibrinogen has been noted to accelerate plasmatic coagulation in patients with divergent conditions involving upregulation of heme oxygenase activity, including hemodialysis, Alzheimer's disease, sickle cell anemia, and chronic migraine. Our goal was to determine if a site of iron-fibrinogen interaction was on the alpha chain. Using thrombelastography, we compared the coagulation kinetic profiles of plasma exposed to 0-10 µM ferric chloride after activation of coagulation with thrombin generated by contact activation of plasma with the plastic sample cup or by exposure to 1 µg/ml of Calloselasma rhodostoma venom (rich in ancrod activity), which causes coagulation via polymerization of alpha chain monomers. Venom mediated coagulation always occurred before thrombin activated thrombus formation, and ferric chloride always diminished the time of onset of coagulation and increased the velocity of clot growth. Iron enhances plasmatic coagulation kinetics by modulating the alpha chain of fibrinogen.

References

Jan 3, 2013·Microscopy Research and Technique·Etheresia PretoriusBoguslaw Lipinski
Jun 1, 2013·Current Neurovascular Research·Boguslaw Lipinski, Etheresia Pretorius
Jul 19, 2013·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Koichi Orino
Apr 16, 2014·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Vance G Nielsen, Etheresia Pretorius
May 21, 2014·Microscopy Research and Technique·Albe C SwanepoelEtheresia Pretorius
Jul 6, 2014·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Vance G Nielsen, Etheresia Pretorius
Sep 19, 2014·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Ryan W MatikaMachaiah Madhrira
Jan 6, 2015·Current Neurovascular Research·Vance G NielsenJoao P Reinhard
May 20, 2015·Journal of Thrombosis and Thrombolysis·Nirmish ShahVance G Nielsen
Aug 22, 2015·CNS & Neurological Disorders Drug Targets·Vance G NielsenRyan W Matika

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Citations

Aug 6, 2016·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Vance G NielsenQuinlan Amos
Aug 23, 2016·Basic & Clinical Pharmacology & Toxicology·Vance G Nielsen, Philip A Losada
Oct 28, 2016·Journal of Thrombosis and Thrombolysis·Vance G Nielsen, Charles M Bazzell
Jul 21, 2017·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Christine S Olver, Vance G Nielsen
Jan 4, 2021·Journal of Thrombosis and Thrombolysis·Vance G Nielsen

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