PMID: 7542998Aug 1, 1995Paper

Iron overload augments the development of atherosclerotic lesions in rabbits

Arteriosclerosis, Thrombosis, and Vascular Biology
J A AraujoJ Cardier

Abstract

Iron, a major oxidant in vivo, could be involved in atherosclerosis through the induction of the formation of oxidized LDL, a major atherogenic factor. This study was designed to test this hypothesis experimentally. Four groups of New Zealand White rabbits were included: iron-overloaded/hypercholesterolemic (group A, n = 8), iron-overloaded (group B, n = 6), hypercholesterolemic (group C, n = 6), and untreated (group D, n = 6). Iron overload was achieved by the intramuscular administration of 1.5 g of iron dextran divided in 30 doses. Hypercholesterolemia was produced by feeding rabbit chow enriched with 0.5% (wt/wt) cholesterol. Serum iron, ferritin, cholesterol, triglycerides, and lipoperoxides in serum were measured throughout the study. Lipoperoxides were measured at the end of the study in liver, aorta, and spleen homogenates. Aortas of groups A and C had multiple lesions; however, group A had greater lesional involvement than group C (P < .05). Lesions were not observed in rabbits fed normal chow (group D). As expected, serum iron and ferritin were above normal levels in groups A and B. Serum cholesterol increased in groups A and C. Lipoperoxides in liver and spleen homogenates of iron-overloaded rabbits were increased. I...Continue Reading

References

Aug 1, 1978·Annals of Internal Medicine·T GordonP M McNamara
Oct 1, 1976·Annals of Internal Medicine·W B KannelT Gordon
Oct 1, 1992·Free Radical Biology & Medicine·H EsterbauerG Jürgens
Jan 1, 1992·Annual Review of Medicine·S ParthasarathyJ L Witztum
Dec 1, 1991·The Journal of Clinical Investigation·J L Witztum, D Steinberg
Feb 1, 1991·European Journal of Haematology·D FuchsH Wachter
Dec 1, 1990·Biochemical Society Transactions·G M Wilkins, D S Leake
Apr 6, 1989·The New England Journal of Medicine·D SteinbergJ L Witztum
May 1, 1989·American Heart Journal·J L Sullivan
Jan 17, 1985·The New England Journal of Medicine·J M McCord
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·T KitaC Kawai
Apr 1, 1987·Physiological Reviews·H A Huebers, C A Finch
Feb 1, 1986·The Journal of Clinical Investigation·S ParthasarathyD Steinberg
Jul 1, 1974·The American Journal of Clinical Nutrition·J D CookC A Finch
May 30, 1974·The New England Journal of Medicine·D A LipschitzC A Finch
Jun 13, 1981·Lancet·J L Sullivan
Jan 1, 1983·Perspectives in Biology and Medicine·J L Sullivan
Jan 1, 1984·Methods in Enzymology·K Yagi
Oct 27, 1994·The New England Journal of Medicine·J T SalonenR Salonen
Apr 21, 1994·The New England Journal of Medicine·C T SemposD M Makuc
Mar 1, 1994·Epidemiology·H I MorrisonD T Wigle

❮ Previous
Next ❯

Citations

Jan 1, 1966·Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere·K Negishi, G Svaetichin
Jan 1, 1966·Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere·K Negishi, G Svaetichin
Dec 11, 2007·Annals of Hematology·Massimo FranchiniGiuseppe Lippi
Apr 29, 2010·Current Heart Failure Reports·Qurat-ul-ain Jelani, Stuart D Katz
Jul 1, 1996·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G W MeijerG J Speijers
Dec 13, 1996·Biochimica Et Biophysica Acta·L DaiC J Morris
May 30, 1998·Atherosclerosis·J E EichnerE Schechter
Feb 17, 2001·The Journal of Nutritional Biochemistry·J L. Sullivan
Jan 1, 1997·Annals of Epidemiology·M C CortiC H Hennekens
Mar 20, 1999·Kidney International. Supplement·J L Sullivan
May 2, 2002·Kidney International. Supplement·Allan J Collins
Aug 29, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M FaillaG Mancia
Oct 5, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W SchneiderhanM G Bachem
Aug 8, 2006·Thyroid : Official Journal of the American Thyroid Association·Henry VölzkeMarcus Dörr
Oct 18, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·K-H ChoiK-H Cho
Nov 10, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·X M Yuan, U T Brunk
Jun 20, 2001·The Journal of Clinical Investigation·E A KirkR C LeBoeuf
Feb 26, 2010·The Journal of Nutrition·Namanjeet AhluwaliaJean-Bernard Ruidavets
Nov 13, 2013·Cellular and Molecular Life Sciences : CMLS·Hjalte Holm AndersenTorben Moos
May 23, 2014·Frontiers in Pharmacology·Francesca VinchiViktória Jeney
Jul 30, 2002·Diabetes·José Manuel Fernández-RealWifredo Ricart
Nov 28, 2002·Diabetes Care·José Manuel Fernández-RealWifredo Ricart
Jul 16, 1999·Vascular Medicine·L D Horwitz, E A Rosenthal
Mar 17, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R T CaladoM A Zago
May 5, 2017·British Journal of Pharmacology·Tin KyawAlex Bobik
Feb 24, 2006·European Journal of Clinical Nutrition·A Soto GonzálezO Vidal
Aug 12, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Seok Kyo SeoByung Seok Lee
Jul 27, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Jeffrey S ArmstrongDean P Jones
Aug 31, 2010·Critical Pathways in Cardiology·Kyu Rae LeeKyung Kon Kim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.