Iron overload impact on P-ATPases

Annals of Hematology
Leilismara SousaLeandro Augusto Barbosa

Abstract

Iron is a chemical element that is active in the fundamental physiological processes for human life, but its burden can be toxic to the body, mainly because of the stimulation of membrane lipid peroxidation. For this reason, the action of iron on many ATPases has been studied, especially on P-ATPases, such as the Na+,K+-ATPase and the Ca2+-ATPase. On the Fe2+-ATPase activity, the free iron acts as an activator, decreasing the intracellular Fe2+and playing a protection role for the cell. On the Ca2+-ATPase activity, the iron overload decreases the enzyme activity, raising the cytoplasmic Ca2+and decreasing the sarco/endoplasmic reticulum and the Golgi apparatus Ca2+concentrations, which could promote an enzyme oxidation, nitration, and fragmentation. However, the iron overload effect on the Na+,K+-ATPase may change according to the tissue expressions. On the renal cells, as well as on the brain and the heart, iron promotes an enzyme inactivation, whereas its effect on the erythrocytes seems to be the opposite, directly stimulating the ATPase activity, or stimulating it by signaling pathways involving ROS and PKC. Modulations in the ATPase activity may impair the ionic transportation, which is essential for cell viability mainten...Continue Reading

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Citations

Aug 21, 2019·Oecologia·Punidan D Jeyasingh, Katja Pulkkinen
Jan 29, 2019·World Journal of Gastroenterology : WJG·Bin ShiHong-Yi Zhang
Dec 4, 2019·Clinica Chimica Acta; International Journal of Clinical Chemistry·Leilismara SousaLeandro A Barbosa
Mar 16, 2021·Food & Function·Marcella Duarte Villas MishimaHércia Stampini Duarte Martino
Apr 13, 2021·International Journal of Pharmaceutics·Riddhi Trivedi, Kalyani Barve
Aug 6, 2021·Oxidative Medicine and Cellular Longevity·Yu-Wei YangJia-Fu Feng
Jun 21, 2021·Experimental Physiology·Renata Andrade ÁvilaLeonardo Dos Santos

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