Iron overload in untransfused patients with hemoglobin H disease

Acta Haematologica
C K LinC H Yung

Abstract

Two Chinese patients with hemoglobin (Hb) H disease without a history of blood transfusion developed iron overload at the age of 45 and 53 years, respectively. Human leukocyte antigen (HLA) system types of these 2 patients were A19, A11, B13, B62 and A2, A24, BW55, respectively, which are not related to the common haplotypes for idiopathic hemochromatosis. Since severe iron loading is a rare clinical manifestation in untransfused patients with Hb H disease, the iron overload in both patients may be due to environmental or underlying genetic factors.

Citations

Jul 1, 1995·Digestive Diseases and Sciences·M OliverP C Adams
Mar 1, 1993·British Journal of Haematology·A ZanellaG Barosi
Oct 24, 2002·Blood·David H K ChuiVivian Chan

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