Iron oxide/gold nanoparticles-decorated reduced graphene oxide nanohybrid as the thermo-radiotherapy agent

IET Nanobiotechnology
Kave MoloudiFarshid Fathi

Abstract

The main focus of the current study is the fabrication of a multifunctional nanohybrid based on graphene oxide (GO)/iron oxide/gold nanoparticles (NPs) as the combinatorial cancer treatment agent. Gold and iron oxide NPs formed on the GONPs via the in situ synthesis approach. The characterisations showed that gold and iron oxide NPs formed onto the GO. Cell toxicity assessment revealed that the fabricated nanohybrid exhibited negligible toxicity against MCF-7 cells in low doses (<50 ppm). Temperature measurement showed a time and dose-dependent heat elevation under the interaction of the nanohybrid with the radio frequency (RF) wave. The highest temperature was recorded using 200 ppm concentration nanohybrid during 40 min exposure. The combinatorial treatments demonstrated that the maximum cell death (average of 53%) was induced with the combination of the nanohybrid with RF waves and radiotherapy (RT). The mechanistic study using the flow cytometry technique illustrated that early apoptosis was the main underlying cell death. Moreover, the dose enhancement factor of 1.63 and 2.63 were obtained from RT and RF, respectively. To sum up, the authors' findings indicated that the prepared nanohybrid could be considered as multifunct...Continue Reading

References

Feb 24, 2001·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·M H Falk, R D Issels
Sep 16, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Rolf D Issels
Feb 23, 2010·The Journal of Physical Chemistry. C, Nanomaterials and Interfaces·Song GeBradford G Orr
Jun 26, 2014·Nanoscale·C B CollinsC J Ackerson
Feb 6, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Tatiana WolfeSunil Krishnan
May 21, 2017·Journal of Photochemistry and Photobiology. B, Biology·Ali NeshastehrizAli Shakeri-Zadeh
Aug 10, 2017·ACS Applied Materials & Interfaces·Sajid FazalDeepthy Menon
Oct 4, 2017·CA: a Cancer Journal for Clinicians·Carol E DeSantisAhmedin Jemal
Oct 4, 2017·Journal of Drug Targeting·Kamyar KhoshnevisanHassan Maleki
Oct 14, 2017·Materials Science & Engineering. C, Materials for Biological Applications·Behzad Adibi-MotlaghEhsan Hashemi
Jan 31, 2018·Current Drug Metabolism·Jian-Ping DouJie Yu
Feb 18, 2018·Drug Development and Industrial Pharmacy·Nahid PoorgholyHamed Hamishehkar
Oct 3, 2018·Materials Science & Engineering. C, Materials for Biological Applications·Raquel O RodriguesAdrián M T Silva
Oct 3, 2018·Materials Science & Engineering. C, Materials for Biological Applications·Farideh MahmoodzadehElnaz Bagherzadeh-Khajehmarjan
Sep 12, 2019·Chemico-biological Interactions·Keywan MortezaeeAmirhossein Ahmadi
Oct 19, 2019·IET Nanobiotechnology·Seyed Mohammad Amini, Abolfazl Akbari
Sep 7, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ravi KumarBijoy Kumar Kuanr

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis