Iron release and ROS generation from mineral particles are not related to cytokine release or apoptosis in exposed A549 cells

Toxicology Letters
J OvrevikP E Schwarze

Abstract

The generation of reactive oxygen species (ROS) by mineral particles is believed to be central to their toxicity and their ability to induce inflammation. Surface bound or soluble iron may contribute to the particle-effects by enhancing the ROS generation through the Fenton reaction. Nevertheless, the importance of ROS and transition metals to mineral particle-induced effects is still unclear and further investigations are needed. In the present study we have investigated different mineral particles for their total iron content, amount of soluble iron at pH 7.0 and 4.0, their ability to generate ROS in a cell-free environment, and their ability to induce cytokine release and apoptosis in a human alveolar epithelial cell line (A549). All the investigated parameters varied considerably between the different particles, with the exception of ability to induce apoptosis. Total iron content did not reflect the amount of soluble iron, and neither total nor soluble iron was correlated with ROS generation. Moreover, iron content and ROS was not correlated with the ability of particles to induce cytokine release or apoptosis. The present results suggest that there is no clear relationship between the particles iron content and ability to...Continue Reading

References

Dec 24, 1997·Environmental Health Perspectives·V CastranovaA Teass
Jun 22, 1999·Thorax·D W Kamp, S A Weitzman
Jun 1, 2000·Journal of Toxicology and Environmental Health. Part a·R B HetlandP E Schwarze
May 1, 2001·The Journal of Laboratory and Clinical Medicine·A AljandaliD W Kamp
Aug 18, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·A ClouterK Donaldson
May 30, 2002·Mutation Research·Roel P F SchinsPaul J A Borm
Apr 23, 2003·Free Radical Biology & Medicine·Arti ShuklaBrooke T Mossman
Jul 26, 2005·Inhalation Toxicology·David BernsteinUNKNOWN ILSI Risk Science Institute Working Group

❮ Previous
Next ❯

Citations

Mar 20, 2013·BioMed Research International·P E SchwarzeJ Øvrevik
Nov 6, 2009·Free Radical Research·Peter MøllerSteffen Loft
Feb 4, 2016·Stem Cells International·Lisa AccomassoClaudia Giachino
Jun 21, 2011·Experimental Biology and Medicine·Bá Vu'o'ng LêJérôme Gay-Quéheillard
Oct 4, 2007·Inhalation Toxicology·P E SchwarzeM Refsnes
Apr 13, 2021·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Habiba BouchabGabriele Saretzki
Apr 20, 2013·Environmental Science & Technology·Miriam E Gerlofs-NijlandFlemming R Cassee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Barrett Esophagus

Barrett’s esophagus if a serious complication of gastroesophageal reflux disease during which the normal esophageal lining changes to tissue that resembles intestinal lining. Here is the latest research.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis