Iron signature in asbestos-induced malignant pleural mesothelioma: A population-based autopsy study

Journal of Toxicology and Environmental Health. Part a
Sergio CrovellaVioletta Borelli

Abstract

Malignant pleural mesothelioma (MPM) is an aggressive cancer with poor prognosis. The development of MPM is frequently linked to inhalation of asbestos fibers. A genetic component of susceptibility to this disease is suggested by the observation that some individuals develop MPM following lower doses of asbestos exposure, whereas others exposed to higher quantities do not seem to be affected. This hypothesis is supported also by frequent reports of MPM familial clustering. Despite the widely recognized role of iron (Fe) in cellular asbestos-induced pulmonary toxicity, the role of the related gene polymorphisms in the etiology of MPM has apparently not been evaluated. Eighty-six single-nucleotide polymorphisms (SNPs) of 10 Fe-metabolism genes were examined by exploiting formalin-fixed paraffin-embedded postmortem samples from 77 patients who died due to MPM (designated AEM) and compared with 48 who were exposed to asbestos but from died in old age of cause other than asbestos (designated AENM). All subjects showed objective signs of asbestos exposure. Three SNPs, localized in the ferritin heavy polypeptide, transferrin, and hephaestin genes, whose frequencies were distributed differently in AEM and AENM populations, were identif...Continue Reading

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Citations

Jul 20, 2016·Journal of Toxicology and Environmental Health. Part a·Matteo GiordaniAhmet Umran Dogan
Oct 6, 2016·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Francine Baumann, Michele Carbone
Oct 6, 2016·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Pascal AndujarDidier Jean
Dec 22, 2017·Journal of Toxicology and Environmental Health. Part a·S CrovellaV Borelli
Mar 10, 2017·Journal of Toxicology and Environmental Health. Part a·Michela CangiottiMaria Francesca Ottaviani
Oct 21, 2016·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·M Ariel Geer WallaceJoachim D Pleil
Oct 6, 2016·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Richard A Lemen
Mar 25, 2017·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Matteo GiordaniLaura Valentini
Jun 8, 2021·Frontiers in Oncology·Paola ZacchiVioletta Borelli

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Methods Mentioned

BETA
x-ray
electrophoresis
Chips
genotyping
PCR

Software Mentioned

SNP Browser
Polyphen
Excel
SITF
SIFT
SDS

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