PMID: 16522911Mar 9, 2006Paper

Iron status and food matrix strongly affect the relative bioavailability of ferric pyrophosphate in humans

The American Journal of Clinical Nutrition
Diego MorettiR F Hurrell

Abstract

Although ferric pyrophosphate is a promising compound for iron fortification of foods, few data are available on the effect of food matrices, processing, and ascorbic acid on its bioavailability. We compared the relative bioavailability (RBV) of ferrous sulfate in an experimental form of micronized dispersible ferric pyrophosphate (MDFP) in a wheat-milk infant cereal given with and without ascorbic acid with the RBV of MDFP from a processed and unprocessed rice meal. A crossover design was used to measure iron absorption in young women (n = 26) from test meals fortified with isotopically labeled [57Fe]-MDFP and [58Fe]-ferrous sulfate, based on erythrocyte incorporation of stable isotope labels 14 d later. Geometric mean iron absorption from the wheat-based meal fortified with MDFP was 2.0% and that from the meal fortified with ferrous sulfate was 3.2% (RBV = 62). The addition of ascorbic acid at a molar ratio of 4:1 to iron increased iron absorption from MDFP to 5.8% and that from ferrous sulfate to 14.8% (RBV = 39). In the rice meals, mean iron absorption from MDFP added to the rice at the time of feeding was 1.7%, and that from ferrous sulfate was 11.6% (RBV = 15). The mean iron absorption from MDFP extruded into artificial r...Continue Reading

References

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Citations

Jan 19, 2007·Journal of the American Society of Nephrology : JASN·Walter H Hörl
Aug 13, 2008·Food and Nutrition Bulletin·Christine HotzTed Greiner
Jun 11, 2014·Annals of the New York Academy of Sciences·Georg SteigerBéatrice Conde-Petit
Jun 9, 2016·The British Journal of Nutrition·Colin I CercamondiDiego Moretti
Jan 15, 2009·European Journal of Nutrition·Mark A RoeSusan J Fairweather-Tait
Jul 24, 2010·Journal of Nutritional Science and Vitaminology·Masayo NakamoriShigeru Yamamoto
Feb 27, 2008·Food and Nutrition Bulletin·Richard F Hurrell
May 31, 2012·Journal of Tropical Pediatrics·Francisco Plácido Nogueira ArcanjoJosefina Aparecida Pellegrini Braga
Jun 28, 2013·The American Journal of Clinical Nutrition·Diego MorettiAlida Melse-Boonstra
Mar 5, 2010·The American Journal of Clinical Nutrition·Richard Hurrell, Ines Egli
Jan 9, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Walter H Hörl
Jun 25, 2013·Animal : an International Journal of Animal Bioscience·Y García, J Díaz-Castro
Dec 18, 2013·Annals of the New York Academy of Sciences·Diego MorettiKlaus Kraemer
Nov 13, 2007·Journal of Food Science·J Parada, J M Aguilera
Aug 28, 2010·Nutrition Reviews·Richard Hurrell
Nov 15, 2006·Proceedings of the National Academy of Sciences of the United States of America·Bruce N Ames

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