Iron status is associated with asthma and lung function in US women

PloS One
Emily P BrighamElizabeth C Matsui

Abstract

Asthma and iron deficiency are common conditions. Whether iron status affects the risk of asthma is unclear. To determine the relationship between iron status and asthma, lung function, and pulmonary inflammation. Relationships between measures of iron status (serum ferritin, serum soluble transferrin receptor (sTfR), and sTfR/log10ferritin (sTfR-F Index)) and asthma, lung function, and pulmonary inflammation were examined in women 20-49 years in the National Health and Nutrition Examination Survey. Logistic, linear, and quadratic regression models accounting for the survey design of NHANES were used to evaluate associations between iron status and asthma-related outcomes and were adjusted for race/ethnicity, age, smoking status, income, and BMI. Approximately 16% reported a lifetime history of asthma, 9% reported current asthma, and 5% reported a recent asthma episode/attack (n = 2906). Increased ferritin (iron stores) was associated with decreased odds of lifetime asthma, current asthma, and asthma attacks/episodes in the range of ferritin linearly correlated with iron stores (20-300ng/ml). The highest quintile of ferritin (>76 ng/ml) was also associated with a decreased odds of asthma. Ferritin levels were not associated wit...Continue Reading

References

Dec 1, 1977·Clinical Science and Molecular Medicine·R W CharltonT H Bothwell
Mar 1, 1992·Journal of General Internal Medicine·G H GuyattC Patterson
Aug 11, 1991·The Journal of Experimental Medicine·C E AlfordP A Campbell
Aug 1, 1990·British Journal of Haematology·J D CookB S Skikne
Oct 1, 1973·Journal of Clinical Pathology·G O WaltersM Worwood
Jan 5, 1999·American Journal of Respiratory and Critical Care Medicine·J L HankinsonK B Fedan
Jun 3, 1999·Transfusion Medicine·K Punnonen, A Rajamäki
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·J BousquetA M Vignola
Feb 13, 2001·The Journal of Nutrition·S J Oppenheimer
Feb 28, 2002·The Journal of Pediatrics·Tsunenobu TamuraKathleen G Nelson
Mar 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Helen L CollinsUlrich E Schaible
May 17, 2002·Journal of Applied Physiology·George M BalanosPeter A Robbins
Jan 8, 2004·The Journal of Investigative Dermatology·Jonathan KantorGeorge Cotsarelis
Aug 31, 2004·The European Respiratory Journal·S O ShaheenALSPAC Study Team
Nov 20, 2004·Nature Reviews. Microbiology·Ulrich E Schaible, Stefan H E Kaufmann
Apr 26, 2006·Journal of the American Academy of Dermatology·Leonid Benjamin TrostEllen Calogeras
Feb 16, 2008·Nature Reviews. Immunology·Peter J Barnes
Mar 5, 2010·The Journal of Allergy and Clinical Immunology·Robert F Lemanske, William W Busse
May 12, 2010·Brain & Development·Noriko KonToshiaki Shimizu
Jul 10, 2010·Lung India : Official Organ of Indian Chest Society·K Ramakrishnan, Ashwin Borade
Apr 12, 2011·The European Respiratory Journal·Christopher J RhodesM R Wilkins
Sep 14, 2011·Clinical and Experimental Immunology·H MaaziA J M van Oosterhout
Mar 30, 2012·Expert Review of Respiratory Medicine·Elin Silverpil, Anders Lindén
Aug 8, 2012·Clinical Chemistry and Laboratory Medicine : CCLM·Rob CastelPaul B Berendes
Oct 17, 2012·International Journal of Clinical Practice·C BuccaG Rolla
Oct 8, 2013·Heart, Lung & Circulation·Vanessa P M van EmpelDavid M Kaye

Citations

Jun 23, 2015·International Journal of Molecular Sciences·Donald S SilverbergDoron Schwartz
Sep 7, 2016·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Andrew J Ghio
May 13, 2017·The International Journal of Biochemistry & Cell Biology·Md Khadem AliJay C Horvat
Mar 19, 2020·The European Respiratory Journal·Md Khadem AliJay C Horvat
Nov 15, 2019·American Journal of Respiratory Cell and Molecular Biology·Kento SatoYoko Shibata
Aug 30, 2019·Lasers in Medical Science·Jehan AlsharnoubiDina Yousri Hussein
Sep 15, 2017·Lipids in Health and Disease·Mohamed El AyedEzzedine Aouani
Apr 4, 2019·International Journal of Biomaterials·Sitaria F SiallaganDeni Noviana
May 6, 2019·American Journal of Respiratory and Critical Care Medicine·Sarah J AlldenAdam J Byrne

Related Concepts

Teens
Anemia
Asthma
Health Surveys
Iron
National Health and Nutrition Examination Survey
Experimental Lung Inflammation
Respiratory Function Tests
Relative Risk
Asthma

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