The aim of this study was to assess the iron balance status in the group of 151 male regular blood donors with normal hemoglobin (Hb) and hematocrit (Ht) level who had given over 10 donations of the whole blood with the frequency of 4-6 units per year. We though to determine the prevalence of iron deficiency in this group of donors and its relationship with the cumulative number of previously given blood, as well as to compare the sensitivity of serum ferritin (FRT) with serum soluble transferrin receptor (sTfR) level in detecting tissular iron stores depletion in donors with normal blood count. The control group comprised 50 age-matched first-time donors. For each donor we determined the blood count, serum iron level, total iron binding capacity (TIBC), transferrin saturation, serum transferrin (TRF), FRT and sTfR level. We determined also serum erythropoietin (EPO) level. In all first-time donors iron metabolism parameters and EPO level were normal. In regular donors following abnormalities were noted: FRT level was below 20 micrograms/l in 75 (49.7%), sTfR was increased in 28 (18.5%) of donors. In the majority of donors with an increase of sTfR level FRT level was decreased (22 out of 28, 78.6%), but sTfR concentration was e...Continue Reading
Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.