Iron Sulfur and Molybdenum Cofactor Enzymes Regulate the Drosophila Life Cycle by Controlling Cell Metabolism

Frontiers in Physiology
Zvonimir MareljaFanis Missirlis

Abstract

Iron sulfur (Fe-S) clusters and the molybdenum cofactor (Moco) are present at enzyme sites, where the active metal facilitates electron transfer. Such enzyme systems are soluble in the mitochondrial matrix, cytosol and nucleus, or embedded in the inner mitochondrial membrane, but virtually absent from the cell secretory pathway. They are of ancient evolutionary origin supporting respiration, DNA replication, transcription, translation, the biosynthesis of steroids, heme, catabolism of purines, hydroxylation of xenobiotics, and cellular sulfur metabolism. Here, Fe-S cluster and Moco biosynthesis in Drosophila melanogaster is reviewed and the multiple biochemical and physiological functions of known Fe-S and Moco enzymes are described. We show that RNA interference of Mocs3 disrupts Moco biosynthesis and the circadian clock. Fe-S-dependent mitochondrial respiration is discussed in the context of germ line and somatic development, stem cell differentiation and aging. The subcellular compartmentalization of the Fe-S and Moco assembly machinery components and their connections to iron sensing mechanisms and intermediary metabolism are emphasized. A biochemically active Fe-S core complex of heterologously expressed fly Nfs1, Isd11, I...Continue Reading

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Citations

Oct 1, 2018·The European Journal of Neuroscience·Yukihiro Yamada, Rebecca A Prosser
Dec 5, 2019·Metallomics : Integrated Biometal Science·Johana Vásquez-ProcopioFanis Missirlis
Jan 3, 2020·PLoS Genetics·Anna Karen Hernández-Gallardo, Fanis Missirlis
Jan 15, 2020·Annual Review of Biochemistry·Roland Lill, Sven-A Freibert
Sep 6, 2019·Cellular and Molecular Life Sciences : CMLS·Shauna-Kay RhoomsEdward Owusu-Ansah
Jun 1, 2018·BioMed Research International·P Calap-QuintanaJ V Llorens
Oct 6, 2018·Genetics·Irene Miguel-AliagaBruno Lemaitre
Jul 11, 2018·International Journal of Molecular Sciences·Véronique MonnierJuan Antonio Navarro
Mar 23, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·Anna Karen Hernández-Gallardo, Fanis Missirlis
Feb 14, 2021·Current Opinion in Insect Science·Fanis Missirlis
Mar 13, 2021·Journal of the Science of Food and Agriculture·Mahmoud M El-SaberAli Osman
May 1, 2021·International Journal of Molecular Sciences·Rebeka PopovicL Miguel Martins
Jun 24, 2021·PLoS Neglected Tropical Diseases·Krystal Maya-MaldonadoFidel de la Cruz Hernández-Hernández

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Methods Mentioned

BETA
electron paramagnetic resonance
electron microscopy

Software Mentioned

Rhythmic Statistic
Blast

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