Iron supplementation and 2-unit red blood cell apheresis: a randomized, double-blind, placebo-controlled study

Transfusion
Hartmut RadtkeHolger Kiesewetter

Abstract

The benefits of 2-unit red blood cell (RBC) apheresis are evident, but iron depletion may be a limiting factor in using this technology. Regular iron supplementation may allow a better utilization of this technique. In this study, 260 regular blood donors donated 2-unit RBCs on each of a total of seven visits at intervals of 8 to 10 weeks. The volunteers were randomly assigned to receive 100 mg of iron(II) or placebo daily. Group A received iron capsules after the first three donations, and Group B after the second three donations, respectively. Hemoglobin, serum ferritin, and serum iron were measured before each donation. Mean serum ferritin concentration decreased after each donation in the placebo phase of both treatment groups, but it remained largely constant during the iron phase in Group A, and even increased during the iron phase in Group B. Regular iron supplementation prevents iron depletion in the majority of donors after 2-unit RBC apheresis within an 8- to 10-week period.

References

Jun 1, 1975·Scandinavian Journal of Haematology·B MagnussonC Siösteen
May 1, 1991·European Journal of Haematology·S D DevasthaliL J Keating
Mar 1, 1990·Transfusion·V R GordeukL J Keating
Jan 1, 1987·Transfusion·V R GordeukL J Keating
Nov 1, 1984·Transfusion·T L SimonP J Garry
May 11, 2001·Transfusion·W HöglerW Nussbaumer

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Citations

Jul 3, 2013·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Maria Luz Dobao GonzálezMilena Bessa
Nov 6, 2012·Revista brasileira de hematologia e hemoterapia·Maria Stella Figueiredo
Nov 6, 2012·Revista brasileira de hematologia e hemoterapia·Rodolfo Delfini Cançado, Dante Langhi
Dec 21, 2012·Current Medical Research and Opinion·María Jesús Cancelo-HidalgoLluís Pérez-Edo
Mar 20, 2013·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Rainer Moog
Oct 15, 2011·Blood Reviews·Karin AmreinCamilla Drexler
Jul 21, 2009·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Alfredo MendroneEster Cerdeira Sabino
Jun 13, 2006·Transfusion Medicine·J F Harrison
Nov 12, 2009·Transfusion Medicine·E A PageJ F Harrison
Sep 1, 2006·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Mark A Popovsky
Mar 4, 2006·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Mark A Popovsky
Sep 27, 2015·Revista brasileira de hematologia e hemoterapia·Eloísa Tedeschi DauarCesar de Almeida-Neto
Nov 20, 2009·Bone·Karin AmreinHarald Dobnig
Jul 6, 2014·The Cochrane Database of Systematic Reviews·Graham A SmithDavid J Roberts

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