Iron Supplementation Attenuates the Inflammatory Status of Anemic Piglets by Regulating Hepcidin

Biological Trace Element Research
Yutian PuHuahua Du

Abstract

Iron deficiency is common throughout the world and has been linked to immunity impairments. Using piglets to model human infants, we assessed the impact of systemic iron homeostasis on proinflammatory status. Artificially reared piglets were parenterally supplied with iron dextran by intramuscular administration at the age of 3 days. Relative to no iron supplementation (control), iron dextran-treated (FeDex) piglets increased hematological parameters as well as iron levels in serum and tissues from days 21 to 49. High expression of hepcidin was observed in FeDex-treated piglets, which correlated with suppressed expression of ferroportin in duodenum. Lower levels of proinflammatory cytokine (IL-6, TNF-α, IFN-γ, and IL-1β) transcripts were detected in ileum of FeDex-treated piglets, which indicated that iron supplementation could attenuate the increase of inflammatory cytokines caused by iron deficiency. Histopathological analysis of liver and duodenum proved the less inflammatory responses after iron supplementation. Hepcidin was highly stimulated by FeDex supplementation and attenuated the inflammation of anemia, which implied that hepcidin might had antiinflammatory function and is a candidate regulator of the cross-talk betwe...Continue Reading

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Citations

Jun 19, 2019·Journal of Child Language·Ryan E Henke
Sep 17, 2019·Alcoholism, Clinical and Experimental Research·Nipun SainiSusan M Smith
May 26, 2020·Reproduction in Domestic Animals = Zuchthygiene·Kandasamy RajamanickamAngappan Mangala Gowri
Jun 26, 2020·Metallomics : Integrated Biometal Science·Haoxuan DingJie Feng
Jun 28, 2018·European Journal of Nutrition·Ana María Caballero ValcárcelMarina Santaella Pascual
Aug 28, 2020·Metallomics : Integrated Biometal Science·Haoxuan DingJie Feng
Feb 25, 2020·Free Radical Biology & Medicine·Andrew J GhioMichael C Madden

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