Iron supplementation brings up a lacking P300 in iron deficient children

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
G A OteroT Fernández

Abstract

A decrease in iron concentration is accompanied by alterations in catecholaminergic and GABAergic neurotransmission systems, important in learning, memory and attention. It was hypothesized that iron deficient children would present attention deficits. A visual-event related potentials (ERPs) study is presented using an oddball paradigm in order to determine the P300 in ID children. After medical examination, blood was obtained from 201 children for a complete hematological study. Two groups were selected, iron deficient (ID) (serum iron <60 microg/dl) and control (C) (serum iron >60 microg/dl). In both groups ERPs were recorded while executing a continuous performance task (oddball paradigm). Afterwards iron levels were restored in ID children by iron supplementation (ID-IS group) and all tests reapplied. ID children almost lacked a P300 in central and parietal regions. After iron supplementation, P300 clearly became evident although its Pz amplitude remained smaller compared to C children. A clear and strong correlation was found between ID and attention alterations in children. Iron supplementation nearly brings the P300 to normal levels although it is not known if the P300 difference in Pz is due to other nutritional/enviro...Continue Reading

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Citations

Jul 23, 2011·Current Psychiatry Reports·Tanya E FroehlichRichard C Gilman
Apr 16, 2013·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·V Soto-InsugaM L Ruiz-Falcó
Jun 24, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Gloria A OteroGustavo Mendieta-Alcántara
May 23, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Sami SchiffPiero Amodio
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Oct 25, 2017·Nutritional Neuroscience·Gloria A OteroGustavo G Mendieta

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