Iron supplementation for restless legs syndrome - A systematic review and meta-analysis

European Journal of Internal Medicine
Tomer AvniAnat Gafter-Gvili

Abstract

Iron supplementation, is recommended for the treatment of restless legs syndrome (RLS). We gathered evidence for the efficacy and safety of iron supplementation for RLS. A systematic review and meta-analysis of randomized controlled trials that compared iron supplementation versus no iron for patients with RLS was performed. Multiple databases were searched. The primary outcome was the effect of iron on the International Restless Legs Syndrome score (IRLSS) at 4 weeks after treatment. For dichotomous data, risk ratios (RR) with 95% confidence intervals (CIs) were estimated and pooled. For continuous data, weighted mean differences (WMD) were calculated. Ten trials fulfilled the inclusion criteria. Iron therapy was associated with a significant decrease of the IRLSS of -3.55 [95% CI (-5.41) - (-1.68)] points and an increase in the percentage of patients with improvement of the IRLSS score, RR of 2.16 [95% CI 1.56-2.98]. IV FCM was associated with improvement in both the IRLSS (WMD of -2.79 (95% CI (-4.62) - (-0.96), 4 trials, I2 = 0%) and on the RLS-QOL by WMD of 8.67 (95% CI 1.68-15). Iron was associated with an increased rate of adverse events RR 2.04 (95% CI 1.46-2.85), which were not severe and not associated with increased ...Continue Reading

Citations

Jan 30, 2020·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Leonard B WeinstockGerhard J Molderings
Jul 18, 2019·MMW Fortschritte der Medizin·Peter Nielsen
Feb 1, 2020·British Journal of Hospital Medicine·David O'Regan, Kirstie N Anderson
May 28, 2020·International Journal of Environmental Research and Public Health·Giuseppe DidatoPaola Lanteri
Jun 30, 2019·Current Neurology and Neuroscience Reports·Paulina Gonzalez-Latapi, Roneil Malkani
Dec 8, 2020·Lancet·Sant-Rayn PasrichaDorine W Swinkels
Jan 25, 2022·Experimental and Therapeutic Medicine·Andrei VlasieMihai Bogdan Cristea

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