PMID: 15227727Jul 1, 2004Paper

Iron supplementation in experimental hyperthyroidism: effects on oxidative stress in skeletal muscle tissue

Yonsei Medical Journal
Hakki Oktay SeymenG Burçak

Abstract

This study was designed to investigate the effects of iron supplementation on the parameters of oxidative stress in the skeletal muscle tissue of hyperthyroidism induced rats. Hyperthyroidism was found to cause an increase in thiobarbituric acid-reactive substances (TBARS) and copper zinc superoxide dismutase (Cu, Zn SOD) activity, but decreases in the glutathione-peroxidase (GSH Px) activity and glutathione (GSH). Iron supplementation caused an increase in TBARS and a decrease in GSH. Iron supplementation in hyperthyroid rats attenuated the hyperthyroid state, but lowered the plasma ferritin level, which is considered an indicator of thyroid hormone action. Iron supplementation caused no additional increase in the TBARS in hyperthyroid rats, ameliorated the decrease in GSH content and abolished the induction of Cu, Zn SOD. Our findings suggested no increase, but a decrease, in the risk of oxidative stress in iron supplemented hyperthyroid rats. Whether supplementation of iron would have similar effects in humans should be further investigated in clinical studies.

Citations

May 21, 2014·Cell and Tissue Research·Sara Santos BernardesAlessandra Lourenço Cecchini
Dec 21, 2012·Cellular and Molecular Life Sciences : CMLS·Paola VendittiSergio Di Meo
Nov 22, 2008·Free Radical Biology & Medicine·Paola VendittiSergio Di Meo
May 23, 2014·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Benjamin ReyDamien Roussel
Aug 14, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Seong-Mo KimSae-Kwang Ku
Jun 9, 2005·American Journal of Physiology. Endocrinology and Metabolism·Juan Manuel MorenoFélix Vargas

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