Iron supplementation of iron-replete Indonesian infants is associated with reduced weight-for-age

Acta Paediatrica
Torbjörn LindBo Lönnerdal

Abstract

General iron supplementation to prevent iron deficiency in infants who are iron sufficient when starting supplementation may adversely affect their health. A secondary analysis to explore the effect of iron supplementation on iron-replete (IR; Hb > or =113 g/L and S-ferritin > or =33 microg/L) or non-iron-replete 6-month-old Indonesian infants participating in a large, randomized trial on iron and zinc supplementation. Among the iron-supplemented IR (Fe-IR, n = 80) infants S-ferritin was, compared to non-iron-supplemented (NS) IR infants (NS-IR, n = 74), significantly higher (47.5 vs. 20.7 microg/L, p = 0.04), and S-zinc significantly lower (9.7 vs. 10.5 micromol/L, p = 0.04). Haemoglobin concentration (Hb) did not differ between the Fe-IR and NS-IR groups. Change in weight-for-age z-score (WAZ) from 6 to 12 months and mean WAZ at 12 months was lower in the Fe-IR group compared to the NS-IR group (-1.45 vs. -1.03, p < 0.001 and -1.97 vs. -1.60, p < 0.001, respectively). There was no difference in morbidity between groups. Iron supplementation of non-iron-replete infants increased Hb and S-ferritin, but did not affect S-zinc or anthropometrical indices. In our study, iron supplementation of IR infants affected WAZ adversely, whe...Continue Reading

References

Jan 1, 1979·The Journal of Pediatrics·P R Dallman, M A Siimes
Mar 1, 1985·The Journal of Nutrition·B SandströmB Lönnerdal
Apr 29, 1998·Archives of Pediatrics & Adolescent Medicine·J M RobbinsG E Schutze
May 10, 2000·The Journal of Nutrition·R S MacDonald
Feb 13, 2001·The Journal of Nutrition·S J Oppenheimer
Nov 16, 2002·BMJ : British Medical Journal·Tarun Gera, H P S Sachdev
May 6, 2003·Journal of Tropical Pediatrics·I MajumdarS Ranga
Nov 9, 2004·European Journal of Clinical Investigation·C HutchinsonC A Geissler
Dec 13, 2006·The American Journal of Clinical Nutrition·Lora L IannottiRobert E Black

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Citations

Mar 7, 2013·European Journal of Clinical Nutrition·W PerngE Villamor
Dec 17, 2008·The American Journal of Clinical Nutrition·Ekhard E ZieglerJanice M Jeter
May 22, 2009·The American Journal of Clinical Nutrition·Ekhard E ZieglerJanice M Jeter
Nov 9, 2011·Nutrition Reviews·Ekhard E ZieglerJanice M Jeter
Mar 17, 2010·BioFactors·Janet Y Uriu-AdamsCarl L Keen
Sep 14, 2015·The Journal of Pediatrics·Nancy F KrebsEkhard Ziegler
Sep 14, 2015·The Journal of Pediatrics·Bo LönnerdalOlle Hernell
Aug 26, 2016·Journal of Clinical Laboratory Analysis·Rongrong ZhaiSongtao Zhang
May 16, 2014·The Cochrane Database of Systematic Reviews·Evan Mayo-WilsonZulfiqar A Bhutta
Dec 21, 2016·The Cochrane Database of Systematic Reviews·Marzia Lazzerini, Humphrey Wanzira
Oct 19, 2013·Journal of Pediatric Gastroenterology and Nutrition·Magnus DomellöfJohannes van Goudoever
Apr 7, 2015·Journal of Pediatric Gastroenterology and Nutrition·Bo Lönnerdal, Olle Hernell
Jul 27, 2017·Journal of Developmental and Behavioral Pediatrics : JDBP·Mohammad Yawar Yakoob, Clifford W Lo
Nov 20, 2014·Journal of Pediatric Gastroenterology and Nutrition·Staffan K BerglundMagnus Domellöf
May 16, 2019·Annual Review of Nutrition·Michael K GeorgieffSarah E Cusick
Jan 7, 2021·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·J C WillcoxA Worsley
Apr 5, 2011·Pediatrics·Olle Hernell, Bo Lönnerdal

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