Abstract
Preoperative anaemia is associated with increased morbidity and mortality. The aim of this systematic review is to evaluate the efficacy of preoperative iron supplementation in the treatment of anaemia, and its effect on the postoperative recovery of patients undergoing surgery for colorectal carcinoma. This systematic review was performed using MEDLINE, EMBASE and the Cochrane library to assess current evidence on the role of iron supplementation in the treatment of preoperative anaemia. Our main outcomes were absolute increase in haemoglobin, blood transfusion rate and postoperative morbidity. Main inclusion criteria were: preoperative iron supplementation, presence of colorectal carcinoma and elective surgery. The Downs-Black questionnaire was used for quality assessment of the included studies. Of the 605 studies analysed, seven, three randomized controlled trials and four cohort studies, were included. Despite iron supplementation, the three randomized controlled trials showed a decrease in haemoglobin level. This was contrary to the four cohort studies which all showed a significant increase. All studies showed a decreased blood transfusion rate following iron supplementation. None of the included studies assessed postope...Continue Reading
References
May 13, 1993·The New England Journal of Medicine·O R BuschJ Jeekel
Oct 28, 1993·The New England Journal of Medicine·S J Winawar
Oct 19, 1996·Lancet·J L CarsonB L Strom
Oct 9, 1998·Journal of Epidemiology and Community Health·S H Downs, N Black
Dec 5, 1998·World Journal of Surgery·N QvistC P Hansen
Feb 14, 2002·The Journal of Surgical Research·James R DunneLena M Napolitano
Dec 29, 2004·Surgery Today·Masaki OkuyamaTakashi Shimano
Jul 14, 2006·Transfusion·Jorge CuencaManuel Muñoz
May 31, 2007·Annals of the Royal College of Surgeons of England·P G LidderK B Hosie
Nov 29, 2007·Anesthesiology·Oliver M TheusingerDonat R Spahn
Mar 29, 2008·British Journal of Anaesthesia·P BerisP Van der Linden
Feb 25, 2009·Archives of Physical Medicine and Rehabilitation·Anna M ChudykMark Speechley
May 5, 2009·Lancet·Julia BohliusAndreas Engert
Jul 28, 2009·Journal of Clinical Epidemiology·David MoherUNKNOWN PRISMA Group
Sep 5, 2009·The British Journal of Surgery·T J EdwardsK B Hosie
Nov 19, 2009·The New England Journal of Medicine·Stefan D AnkerUNKNOWN FAIR-HF Trial Investigators
Jun 25, 2010·Annals of the Royal College of Surgeons of England·Martha QuinnAngus Macdonald
May 13, 2011·Gut·Andrew F GoddardUNKNOWN British Society of Gastroenterology
May 21, 2011·Annals of Surgery·Malaika S VlugUNKNOWN LAFA study group
Jun 28, 2011·Gastroenterology·Rayko EvstatievUNKNOWN FERGI Study Group
Aug 16, 2011·British Journal of Anaesthesia·E BisbeUNKNOWN Anaemia Working Group España
Oct 11, 2011·Lancet·Khaled M MusallamFaek R Jamali
Apr 19, 2012·British Journal of Haematology·Sue PavordUNKNOWN British Committee for Standards in Haematology
Mar 4, 2014·World Journal of Gastroenterology : WJG·Manuel MuñozMichael Auerbach
Jun 12, 2014·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·B D KeelerA G Acheson
Citations
Jan 17, 2017·The British Journal of Surgery·B D KeelerUNKNOWN IVICA Trial Group
Oct 3, 2018·Pharmaceuticals·Fabiana BustiDomenico Girelli
May 15, 2019·European Journal of Gastroenterology & Hepatology·Grace H TangChristine Brezden-Masley
Jan 20, 2018·Scientific Reports·Juha P VäyrynenMarkus J Mäkinen
Sep 11, 2017·International Journal of Colorectal Disease·M J WilsonJ J Zwaginga
May 26, 2018·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·J CoussirouP Debourdeau
Jun 2, 2018·Gastroenterology Research and Practice·Liu LiuQiang Huang
Aug 3, 2019·Der Anaesthesist·C RosenthalL Kaufner
Feb 2, 2021·Langenbeck's Archives of Surgery·Jadie PlückerMarkus A Weigand
Feb 16, 2021·Hematology, Transfusion and Cell Therapy·Sheikh Muhammad Ebad AliMahwish Rehman
Mar 30, 2021·Frontiers in Immunology·Aysegül AksanJürgen Stein
Jun 25, 2021·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Rasmus Dahlin BojesenIsmail Gogenür
Aug 27, 2021·Current Oncology·Chao-Ming HungPing-Tao Tseng
Dec 11, 2021·Nutrition and Cancer·Gang TangZhengqiang Wei