Iron therapy for the treatment of preoperative anaemia in patients with colorectal carcinoma: a systematic review

Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland
W A A BorstlapW A Bemelman

Abstract

Preoperative anaemia is associated with increased morbidity and mortality. The aim of this systematic review is to evaluate the efficacy of preoperative iron supplementation in the treatment of anaemia, and its effect on the postoperative recovery of patients undergoing surgery for colorectal carcinoma. This systematic review was performed using MEDLINE, EMBASE and the Cochrane library to assess current evidence on the role of iron supplementation in the treatment of preoperative anaemia. Our main outcomes were absolute increase in haemoglobin, blood transfusion rate and postoperative morbidity. Main inclusion criteria were: preoperative iron supplementation, presence of colorectal carcinoma and elective surgery. The Downs-Black questionnaire was used for quality assessment of the included studies. Of the 605 studies analysed, seven, three randomized controlled trials and four cohort studies, were included. Despite iron supplementation, the three randomized controlled trials showed a decrease in haemoglobin level. This was contrary to the four cohort studies which all showed a significant increase. All studies showed a decreased blood transfusion rate following iron supplementation. None of the included studies assessed postope...Continue Reading

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Citations

Jan 17, 2017·The British Journal of Surgery·B D KeelerUNKNOWN IVICA Trial Group
Oct 3, 2018·Pharmaceuticals·Fabiana BustiDomenico Girelli
May 15, 2019·European Journal of Gastroenterology & Hepatology·Grace H TangChristine Brezden-Masley
Sep 11, 2017·International Journal of Colorectal Disease·M J WilsonJ J Zwaginga
May 26, 2018·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·J CoussirouP Debourdeau
Jun 2, 2018·Gastroenterology Research and Practice·Liu LiuQiang Huang
Aug 3, 2019·Der Anaesthesist·C RosenthalL Kaufner
Feb 2, 2021·Langenbeck's Archives of Surgery·Jadie PlückerMarkus A Weigand
Mar 30, 2021·Frontiers in Immunology·Aysegül AksanJürgen Stein
Jun 25, 2021·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Rasmus Dahlin BojesenIsmail Gogenür

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