Iron therapy resistant microcytic anaemia in a 13-year-old girl with Castleman disease

European Journal of Pediatrics
T A De Heer-GroenP J van Dijken

Abstract

We describe the case history of a 13-year-old girl with chronic fatigue and prolonged microcytic anaemia. She received oral iron since the age of 11 but failed to respond to it. Laboratory studies revealed elevated C-reactive protein and hypergammaglobulinaemia. A large solitary mesenterial lymph node could be demonstrated by ultrasonography and CT. A diagnosis of Castleman disease was suspected and confirmed histologically. After surgical removal of the lymphoma the patient recovered completely. Castleman disease should be considered in cases of chronic fatigue, unexplained fever, microcytic anaemia and hypergammaglobulinaemia.

References

Sep 1, 1992·Investigative Radiology·G J Burke, J Wei
Nov 1, 1991·Pediatric Pathology·R Drut, A Larregina
Jul 15, 1993·The New England Journal of Medicine·F A Oski
Jul 1, 1956·Cancer·B CASTLEMANV P MENENDEZ

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Citations

Sep 17, 2011·Surgery Today·Mitsuhiko OhtaTeruyoshi Ishida
Nov 20, 1998·Journal of Pediatric Gastroenterology and Nutrition·M D RodefeldJ C Langer
Sep 22, 2011·Onkologie·Chien-Hsiang WengTseng-Hsi Lin
Jun 9, 2005·World Journal of Surgical Oncology·Pascal BucherPhilippe Morel
Mar 21, 1998·Lancet·D R McCluskeyW G McCluggage

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