Iron transport kinetics through blood-brain barrier endothelial cells

Biochimica Et Biophysica Acta. General Subjects
Aminul Islam KhanPrashanta Dutta

Abstract

Transferrin and its receptors play an important role during the uptake and transcytosis of iron through blood-brain barrier (BBB) endothelial cells (ECs) to maintain iron homeostasis in BBB endothelium and brain. Any disruptions in the cell environment may change the distribution of transferrin receptors on the cell surface, which eventually alter the homeostasis and initiate neurodegenerative disorders. In this paper, we developed a comprehensive mathematical model that considers the necessary kinetics for holo-transferrin internalization and acidification, apo-transferrin recycling, and exocytosis of free iron and transferrin-bound iron through basolateral side of BBB ECs. Ordinary differential equations are formulated based on the first order reaction kinetics to model the iron transport considering their interactions with transferrin and transferrin receptors. Unknown kinetics rate constants are determined from experimental data by applying a non-linear optimization technique. Using the estimated kinetic rate constants, the presented model can effectively reproduce the experimental data of iron transports through BBB ECs for many in-vitro studies. Model results also suggest that the BBB ECs can regulate the extent of the tw...Continue Reading

Citations

Jun 14, 2019·Biological Reviews of the Cambridge Philosophical Society·Zhong-Ming Qian, Ya Ke
Feb 25, 2020·Current Pharmaceutical Design·Yoichi Morofuji, Shinsuke Nakagawa
Jan 9, 2020·Biological Trace Element Research·XueJie LiuXueLi Gao
Sep 2, 2020·Nutrients·Tanja Grubić Kezele, Božena Ćurko-Cofek
Aug 4, 2019·Progress in Neurobiology·Kasper Bendix JohnsenTorben Moos
Nov 5, 2019·Biochimica Et Biophysica Acta. General Subjects·Aminul Islam KhanPrashanta Dutta
Dec 12, 2020·The Journal of Pharmacology and Experimental Therapeutics·Nidhi ShardaKarunya K Kandimalla
Sep 27, 2018·Biochimica Et Biophysica Acta. General Subjects·Aminul Islam KhanPrashanta Dutta
Jun 18, 2021·Seminars in Cancer Biology·Peter W HalcrowJoyce E Ohm

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