PMID: 8970483Dec 1, 1996Paper

Iron versus cholesterol--perspectives on the iron and heart disease debate

Journal of Clinical Epidemiology
J L. Sullivan

Abstract

Focusing only on the limited question of whether stored iron is a valid heart disease risk factor inappropriately narrows the scope of the debate on the "iron hypothesis." Framing the debate in this way ignores the broad explanatory power of the hypothesis that iron depletion protects against ischemic heart disease. The iron hypothesis provides a conceptual tool for study of the mechanisms by which age and gender influence the development of ischemic heart disease. The assumption that age and gender exert unalterable effects has diverted attention from these strong risk factors, and has led to intense preoccupation with weaker risk factors such as cholesterol. The notion that cholesterol is of central importance has become a rigid and institutionalized point of view. Increased mortality from some cholesterol-lowering drugs is but one of the potential dangers of continued promotion of the flawed idea that heart disease is a function of the cholesterol concentration. The more serious risk is that alternative approaches to the problem of ischemic heart disease will be suppressed. Consideration of the relationship between the iron and cholesterol hypotheses provides important perspectives on the current debate on the role of iron i...Continue Reading

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Citations

Jul 10, 2003·The Journal of Surgical Research·Ralph G DePalmaMark R Hall
Apr 3, 2001·Archives of Medical Research·R Monge-Rojas
Dec 1, 1996·Journal of Clinical Epidemiology·J L Sullivan
Feb 17, 2001·The Journal of Nutritional Biochemistry·J L. Sullivan
May 31, 2001·European Journal of Clinical Investigation·J L Sullivan, L R Zacharski
Mar 20, 1999·Kidney International. Supplement·J L Sullivan
May 2, 2002·Kidney International. Supplement·Allan J Collins
Dec 28, 1999·The New England Journal of Medicine·M RosénN Hammar
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Jun 21, 2011·Genes & Development·Li ZhangJohn W R Schwabe
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Oct 8, 1999·Emerging Infectious Diseases·J L Sullivan, E D Weinberg
Sep 24, 1999·Circulation·J L Sullivan
Dec 25, 2009·Circulation. Cardiovascular Genetics·Jerome L Sullivan
Feb 15, 2012·Fetal and Pediatric Pathology·Larissa V FurtadoJohn M Opitz
Nov 19, 2015·Molecular Nutrition & Food Research·Johann GuillemotNabil G Seidah
Aug 29, 2002·The American Journal of Clinical Nutrition·Christopher T Sempos

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